Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial

BE0003887ProteinHumansETFDH

Links fatty acid beta-oxidation and amino acid catabolism to the respiratory chain by transferring electrons from the electron transfer flavoprotein (ETF) to ubiquinone. It is acted on by 2 drugs in DrugBank.

Gene name
ETFDH
UniProtKB entry
Q16134Swiss-Prot
Cellular location
Mitochondrion inner membrane
Residues / weight
617 residues · 68,495 Da
Also known as
1.5.5.1 · Electron-transferring-flavoprotein dehydrogenase · ETF dehydrogenase · ETF-QO · ETF-ubiquinone oxidoreductase

Resolves to

Protein
UniProtQ16134UniProt nameETFD_HUMAN
Gene
HGNCHGNC:3483NCBI Gene2110GenBank545621GeneCardsETFDH
Pharmacology
KEGGhsa:2110
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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11GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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13+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial, how selective are they, and which programs against it are still in active trials?

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