Cytochrome c oxidase subunit 1

Details

Name
Cytochrome c oxidase subunit 1
Kind
protein
Synonyms
  • 1.9.3.1
  • Cytochrome c ba(3) subunit I
  • Cytochrome c oxidase polypeptide I
  • Cytochrome cba3 subunit 1
Gene Name
cbaA
UniProtKB Entry
Q5SJ79Swiss-Prot
Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
NCBI Taxonomy ID
300852
Amino acid sequence
>lcl|BSEQ0012715|Cytochrome c oxidase subunit 1
MAVRASEISRVYEAYPEKKATLYFLVLGFLALIVGSLFGPFQALNYGNVDAYPLLKRLLP
FVQSYYQGLTLHGVLNAIVFTQLFAQAIMVYLPARELNMRPNMGLMWLSWWMAFIGLVVA
ALPLLANEATVLYTFYPPLKGHWAFYLGASVFVLSTWVSIYIVLDLWRRWKAANPGKVTP
LVTYMAVVFWLMWFLASLGLVLEAVLFLLPWSFGLVEGVDPLVARTLFWWTGHPIVYFWL
LPAYAIIYTILPKQAGGKLVSDPMARLAFLLFLLLSTPVGFHHQFADPGIDPTWKMIHSV
LTLFVAVPSLMTAFTVAASLEFAGRLRGGRGLFGWIRALPWDNPAFVAPVLGLLGFIPGG
AGGIVNASFTLDYVVHNTAWVPGHFHLQVASLVTLTAMGSLYWLLPNLTGKPISDAQRRL
GLAVVWLWFLGMMIMAVGLHWAGLLNVPRRAYIAQVPDAYPHAAVPMVFNVLAGIVLLVA
LLLFIYGLFSVLLSRERKPELAEAPLPFAEVISGPEDRRLVLAMDRIGFWFAVAAILVVL
AYGPTLVQLFGHLNPVPGWRLW
Number of residues
562
Molecular Weight
62526.995
Theoretical pI
9.78
GO Classification
Functions
cytochrome-c oxidase activity / heme binding / iron ion binding
Processes
aerobic respiration / oxidative phosphorylation
Components
integral component of membrane / plasma membrane / respiratory chain
General Function
Not Available
Specific Function
cytochrome-c oxidase activity
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
21-41 74-94 105-125 144-164 187-207 227-247 267-287 300-320 345-365 385-405 420-440 471-491 527-547
Cellular Location
Cell membrane
Gene sequence
>lcl|BSEQ0012716|Cytochrome c oxidase subunit 1 (cbaA)
ATGGCGGTGCGCGCAAGCGAGATTAGCCGGGTCTACGAGGCCTATCCGGAGAAGAAGGCG
ACCCTCTACTTCCTGGTCCTGGGCTTCCTCGCCCTCATCGTGGGGAGCCTCTTCGGCCCC
TTCCAGGCCCTGAACTACGGGAACGTGGACGCCTATCCCCTTCTCAAGCGCCTCCTTCCC
TTCGTCCAGTCCTACTACCAGGGCCTGACTTTGCACGGGGTCCTGAACGCCATCGTCTTC
ACCCAGCTCTTCGCCCAGGCCATCATGGTCTACCTGCCCGCTAGGGAGCTGAACATGCGG
CCCAACATGGGCCTCATGTGGCTCTCCTGGTGGATGGCCTTCATCGGGCTCGTGGTGGCC
GCCCTCCCCCTCCTCGCCAACGAGGCCACGGTGCTTTACACCTTCTACCCGCCCCTCAAG
GGGCACTGGGCCTTCTATTTGGGGGCGAGCGTCTTCGTCCTCTCCACCTGGGTGAGCATC
TACATCGTCCTGGACCTCTGGCGGCGCTGGAAGGCGGCGAACCCAGGGAAGGTGACCCCC
TTGGTCACCTACATGGCCGTGGTCTTCTGGCTCATGTGGTTCCTCGCCTCCCTCGGGCTC
GTGCTGGAGGCGGTCCTCTTCCTCCTCCCCTGGTCCTTCGGCCTGGTGGAGGGCGTGGAC
CCCTTGGTCGCCCGCACCCTCTTCTGGTGGACGGGCCACCCCATCGTCTACTTCTGGCTC
CTGCCCGCCTACGCCATCATCTACACCATCCTTCCTAAGCAGGCCGGGGGGAAGCTGGTC
TCCGACCCCATGGCCCGCCTCGCCTTCCTCCTCTTCCTCCTCCTCTCCACCCCCGTGGGC
TTTCACCACCAGTTCGCCGACCCCGGGATTGACCCCACCTGGAAGATGATCCACTCCGTC
CTCACCCTCTTCGTGGCCGTGCCGAGCCTCATGACCGCCTTCACCGTCGCGGCGAGCCTG
GAGTTCGCGGGGCGCCTCAGGGGCGGCAGGGGGCTTTTCGGCTGGATCCGGGCCCTCCCC
TGGGACAACCCCGCCTTCGTGGCTCCGGTCCTGGGCCTTTTGGGCTTCATCCCCGGGGGC
GCCGGGGGCATCGTGAACGCCAGCTTCACCCTGGACTACGTGGTGCACAACACCGCCTGG
GTTCCCGGCCACTTCCACCTCCAGGTGGCGAGCCTCGTGACCCTCACCGCCATGGGCTCC
CTCTACTGGCTCCTCCCCAACCTCACGGGCAAGCCCATCTCCGACGCGCAAAGGCGGCTC
GGCCTGGCGGTGGTGTGGCTCTGGTTCCTCGGCATGATGATCATGGCCGTTGGCCTCCAC
TGGGCGGGGCTTCTCAACGTGCCCCGGCGGGCCTACATCGCCCAGGTGCCGGACGCCTAC
CCCCATGCGGCGGTCCCCATGGTGTTCAACGTCCTGGCGGGGATCGTCCTCCTGGTGGCG
CTCCTCCTTTTCATCTACGGCCTCTTCAGCGTCCTCCTTTCCCGGGAAAGGAAGCCCGAG
CTGGCGGAGGCCCCCCTTCCCTTCGCCGAGGTGATCTCCGGTCCCGAGGACCGCAGGCTC
GTCCTGGCCATGGACCGGATCGGGTTCTGGTTCGCCGTGGCGGCGATCCTCGTGGTCCTG
GCCTACGGGCCCACCCTGGTGCAGCTTTTCGGCCACCTCAACCCCGTGCCGGGGTGGCGG
CTCTGGTAG
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDQ5SJ79
UniProtKB Entry NameCOX1_THET8
GenBank Protein ID5053134
GenBank Gene IDL09121
PDB ID(s)1EHK, 2QPD, 2QPE, 3BVD, 3EH3, 3EH4, 3EH5, 3QJQ, 3QJR, 3QJS, 3QJT, 3QJU, 3QJV, 3S33, 3S38, 3S39, 3S3A, 3S3B, 3S3C, 3S3D, 3S8F, 3S8G, 4FA7, 4FAA, 4G70, 4G71, 4G72, 4G7Q, 4G7R, 4G7S, 4GP4, 4GP5, 4GP8, 4N4Y
KEGG IDttj:TTHA1135
NCBI Gene ID3168993
General References
  1. Keightley JA, Zimmermann BH, Mather MW, Springer P, Pastuszyn A, Lawrence DM, Fee JA: Molecular genetic and protein chemical characterization of the cytochrome ba3 from Thermus thermophilus HB8. J Biol Chem. 1995 Sep 1;270(35):20345-58. [Article]
  2. Buse G, Soulimane T, Dewor M, Meyer HE, Bluggel M: Evidence for a copper-coordinated histidine-tyrosine cross-link in the active site of cytochrome oxidase. Protein Sci. 1999 May;8(5):985-90. [Article]
  3. Soulimane T, Buse G, Bourenkov GP, Bartunik HD, Huber R, Than ME: Structure and mechanism of the aberrant ba(3)-cytochrome c oxidase from thermus thermophilus. EMBO J. 2000 Apr 17;19(8):1766-76. [Article]

Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
B-nonylglucosideexperimentalunknowntargetDetails