Colipase
Details
- Name
- Colipase
- Kind
- protein
- Synonyms
- Not Available
- Gene Name
- CLPS
- UniProtKB Entry
- P04118Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0017263|Colipase MEKILILLLVALSVAYAAPGPRGIIINLENGELCMNSAQCKSNCCQHSSALGLARCTSMA SENSECSVKTLYGIYYKCPCERGLTCEGDKTIVGSITNTNFGICHDAGRSKQ
- Number of residues
- 112
- Molecular Weight
- 11953.685
- Theoretical pI
- 7.57
- GO Classification
- Functionsenzyme activator activityProcesseslipid catabolic process / lipid metabolic process / response to foodComponentsextracellular region
- General Function
- Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase
- Specific Function
- enzyme activator activity
- Pfam Domain Function
- Signal Regions
- 1-17
- Transmembrane Regions
- Not Available
- Cellular Location
- Secreted
- Gene sequence
>lcl|BSEQ0007466|339 bp ATGGAGAAGATCCTGATCCTCCTGCTTGTCGCCCTCTCTGTGGCCTATGCAGCTCCTGGC CCCCGGGGGATCATTATCAACCTGGAGAACGGTGAGCTCTGCATGAATAGTGCCCAGTGT AAGAGCAATTGCTGCCAGCATTCAAGTGCGCTGGGCCTGGCCCGCTGCACATCCATGGCC AGCGAGAACAGCGAGTGCTCTGTCAAGACGCTCTATGGGATTTACTACAAGTGTCCCTGT GAGCGTGGCCTGACCTGTGAGGGAGACAAGACCATCGTGGGCTCCATCACCAACACCAAC TTTGGCATCTGCCATGACGCTGGACGCTCCAAGCAGTGA
- Chromosome Location
- 6
- Locus
- 6p21.31
- External Identifiers
Resource Link UniProtKB ID P04118 UniProtKB Entry Name COL_HUMAN GenBank Protein ID 180886 GenBank Gene ID J02883 GeneCard ID CLPS HGNC ID HGNC:2085 KEGG ID hsa:1208 NCBI Gene ID 1208 - General References
- Lowe ME, Rosenblum JL, McEwen P, Strauss AW: Cloning and characterization of the human colipase cDNA. Biochemistry. 1990 Jan 23;29(3):823-8. [Article]
- Sims HF, Lowe ME: The human colipase gene: isolation, chromosomal location, and tissue-specific expression. Biochemistry. 1992 Aug 11;31(31):7120-5. [Article]
- Mungall AJ, Palmer SA, Sims SK, Edwards CA, Ashurst JL, Wilming L, Jones MC, Horton R, Hunt SE, Scott CE, Gilbert JG, Clamp ME, Bethel G, Milne S, Ainscough R, Almeida JP, Ambrose KD, Andrews TD, Ashwell RI, Babbage AK, Bagguley CL, Bailey J, Banerjee R, Barker DJ, Barlow KF, Bates K, Beare DM, Beasley H, Beasley O, Bird CP, Blakey S, Bray-Allen S, Brook J, Brown AJ, Brown JY, Burford DC, Burrill W, Burton J, Carder C, Carter NP, Chapman JC, Clark SY, Clark G, Clee CM, Clegg S, Cobley V, Collier RE, Collins JE, Colman LK, Corby NR, Coville GJ, Culley KM, Dhami P, Davies J, Dunn M, Earthrowl ME, Ellington AE, Evans KA, Faulkner L, Francis MD, Frankish A, Frankland J, French L, Garner P, Garnett J, Ghori MJ, Gilby LM, Gillson CJ, Glithero RJ, Grafham DV, Grant M, Gribble S, Griffiths C, Griffiths M, Hall R, Halls KS, Hammond S, Harley JL, Hart EA, Heath PD, Heathcott R, Holmes SJ, Howden PJ, Howe KL, Howell GR, Huckle E, Humphray SJ, Humphries MD, Hunt AR, Johnson CM, Joy AA, Kay M, Keenan SJ, Kimberley AM, King A, Laird GK, Langford C, Lawlor S, Leongamornlert DA, Leversha M, Lloyd CR, Lloyd DM, Loveland JE, Lovell J, Martin S, Mashreghi-Mohammadi M, Maslen GL, Matthews L, McCann OT, McLaren SJ, McLay K, McMurray A, Moore MJ, Mullikin JC, Niblett D, Nickerson T, Novik KL, Oliver K, Overton-Larty EK, Parker A, Patel R, Pearce AV, Peck AI, Phillimore B, Phillips S, Plumb RW, Porter KM, Ramsey Y, Ranby SA, Rice CM, Ross MT, Searle SM, Sehra HK, Sheridan E, Skuce CD, Smith S, Smith M, Spraggon L, Squares SL, Steward CA, Sycamore N, Tamlyn-Hall G, Tester J, Theaker AJ, Thomas DW, Thorpe A, Tracey A, Tromans A, Tubby B, Wall M, Wallis JM, West AP, White SS, Whitehead SL, Whittaker H, Wild A, Willey DJ, Wilmer TE, Wood JM, Wray PW, Wyatt JC, Young L, Younger RM, Bentley DR, Coulson A, Durbin R, Hubbard T, Sulston JE, Dunham I, Rogers J, Beck S: The DNA sequence and analysis of human chromosome 6. Nature. 2003 Oct 23;425(6960):805-11. [Article]
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- Sternby B, Engstrom A, Hellman U, Vihert AM, Sternby NH, Borgstrom B: The primary sequence of human pancreatic colipase. Biochim Biophys Acta. 1984 Jan 18;784(1):75-80. [Article]
- van Tilbeurgh H, Egloff MP, Martinez C, Rugani N, Verger R, Cambillau C: Interfacial activation of the lipase-procolipase complex by mixed micelles revealed by X-ray crystallography. Nature. 1993 Apr 29;362(6423):814-20. [Article]
- Lindner I, Helwig U, Rubin D, Li Y, Fisher E, Boeing H, Mohlig M, Spranger J, Pfeiffer A, Hampe J, Schreiber S, Doring F, Schrezenmeir J: Putative association between a new polymorphism in exon 3 (Arg109Cys) of the pancreatic colipase gene and type 2 diabetes mellitus in two independent Caucasian study populations. Mol Nutr Food Res. 2005 Oct;49(10):972-6. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details B-nonylglucoside experimental unknown target Details (Hydroxyethyloxy)Tri(Ethyloxy)Octane experimental unknown target Details METHOXYUNDECYLPHOSPHINIC ACID experimental unknown target Details