Proteasome subunit alpha type-2

BE0003911ProteinHumansPSMA2

Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. It is acted on by 1 drug in DrugBank.

Gene name
PSMA2
UniProtKB entry
P25787Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
234 residues · 25,898 Da
Also known as
alpha-2 · HC3 · Macropain subunit C3 · Multicatalytic endopeptidase complex subunit C3 · Proteasome component C3

Resolves to

Protein
UniProtP25787UniProt namePSA2_HUMAN
Gene
HGNCHGNC:9531NCBI Gene5683GenBank220024GeneCardsPSMA2
Pharmacology
KEGGhsa:5683
Structure
PDB4R3OPDB4R67PDB5A0Q
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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31GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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17+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Proteasome subunit alpha type-2, and which indications are they being tested in?

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