Proteasome subunit alpha type-3

BE0003912ProteinHumansPSMA3

Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. It is acted on by 2 drugs in DrugBank.

Gene name
PSMA3
UniProtKB entry
P25788Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
255 residues · 28,433 Da
Also known as
alpha-7 · HC8 · Macropain subunit C8 · Multicatalytic endopeptidase complex subunit C8 · Proteasome component C8

Resolves to

Protein
UniProtP25788UniProt namePSA3_HUMAN
Gene
HGNCHGNC:9532NCBI Gene5684GenBank220028GeneCardsPSMA3
Pharmacology
KEGGhsa:5684
Structure
PDB4R3OPDB4R67PDB5A0Q
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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28GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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34+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Proteasome subunit alpha type-3, and which indications are they being tested in?

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