Transporter
Details
- Name
- Transporter
- Kind
- protein
- Synonyms
- Not Available
- Gene Name
- snf
- UniProtKB Entry
- O67854TrEMBL
- Organism
- Aquifex aeolicus (strain VF5)
- NCBI Taxonomy ID
- 224324
- Amino acid sequence
>lcl|BSEQ0012739|Transporter MEVKREHWATRLGLILAMAGNAVGLGNFLRFPVQAAENGGGAFMIPYIIAFLLVGIPLMW IEWAMGRYGGAQGHGTTPAIFYLLWRNRFAKILGVFGLWIPLVVAIYYVYIESWTLGFAI KFLVGLVPEPPPNATDPDSILRPFKEFLYSYIGVPKGDEPILKPSLFAYIVFLITMFINV SILIRGISKGIERFAKIAMPTLFILAVFLVIRVFLLETPNGTAADGLNFLWTPDFEKLKD PGVWIAAVGQIFFTLSLGFGAIITYASYVRKDQDIVLSGLTAATLNEKAEVILGGSISIP AAVAFFGVANAVAIAKAGAFNLGFITLPAIFSQTAGGTFLGFLWFFLLFFAGLTSSIAIM QPMIAFLEDELKLSRKHAVLWTAAIVFFSAHLVMFLNKSLDEMDFWAGTIGVVFFGLTEL IIFFWIFGADKAWEEINRGGIIKVPRIYYYVMRYITPAFLAVLLVVWAREYIPKIMEETH WTVWITRFYIIGLFLFLTFLVFLAERRRNHESA
- Number of residues
- 513
- Molecular Weight
- 57407.51
- Theoretical pI
- 9.17
- GO Classification
- FunctionsneurotransmitterComponentsintegral component of membrane
- General Function
- Not Available
- Specific Function
- Not Available
- Pfam Domain Function
- SNF (PF00209)
- Signal Regions
- Not Available
- Transmembrane Regions
- 12-29 41-61 92-111 166-185 197-215 243-268 289-314 342-367 379-399 405-427 447-469 481-504
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0012740|Transporter (snf) ATGGAAGTTAAAAGGGAACACTGGGCGACGCGACTCGGTTTAATCCTCGCGATGGCGGGG AACGCGGTAGGACTTGGTAATTTCCTCAGATTTCCCGTTCAAGCTGCGGAAAACGGTGGC GGGGCTTTCATGATCCCATACATAATAGCCTTCCTCCTCGTGGGTATTCCTCTTATGTGG ATAGAGTGGGCTATGGGAAGATACGGGGGAGCTCAGGGACACGGAACCACACCAGCTATT TTTTACCTCCTCTGGAGAAACAGGTTTGCTAAAATTCTTGGAGTTTTCGGACTCTGGATA CCTCTGGTGGTAGCCATATACTACGTTTACATAGAGAGCTGGACACTAGGTTTTGCGATA AAGTTTTTGGTAGGGTTAGTTCCAGAACCTCCGCCAAACGCCACGGATCCCGATTCCATT CTCAGACCCTTTAAAGAATTTCTGTACTCCTACATCGGAGTTCCTAAAGGAGATGAGCCG ATTTTGAAACCTTCACTTTTTGCGTACATAGTCTTTTTAATAACTATGTTCATTAACGTT TCCATTCTCATAAGGGGTATATCCAAGGGTATAGAGAGGTTTGCAAAAATAGCTATGCCC ACGCTCTTTATCCTCGCGGTTTTTCTGGTCATCAGGGTCTTTTTACTGGAAACCCCCAAC GGCACCGCGGCGGACGGACTTAACTTCCTTTGGACTCCCGACTTTGAGAAATTAAAGGAC CCGGGCGTCTGGATAGCGGCTGTAGGACAAATATTCTTCACCCTGAGTCTTGGTTTTGGA GCTATAATCACTTACGCCTCTTACGTGAGAAAGGATCAGGACATTGTCCTCAGCGGACTT ACGGCGGCGACGTTGAACGAAAAGGCTGAGGTAATACTGGGTGGTTCTATTTCCATACCC GCTGCGGTTGCTTTCTTCGGAGTTGCAAATGCGGTTGCGATTGCAAAGGCGGGAGCCTTT AACCTCGGTTTTATAACCCTACCCGCCATATTCTCCCAAACGGCCGGAGGAACCTTTTTA GGATTTCTGTGGTTCTTCCTCCTCTTCTTCGCAGGACTCACTTCTTCAATAGCTATAATG CAACCGATGATAGCCTTCTTAGAGGACGAACTAAAGCTTAGCAGAAAACACGCTGTTCTC TGGACCGCGGCTATAGTTTTCTTCAGTGCACACCTTGTGATGTTCTTAAACAAGTCCCTT GACGAGATGGACTTCTGGGCGGGAACGATAGGGGTTGTTTTCTTTGGTCTCACAGAGCTC ATAATCTTCTTCTGGATTTTCGGAGCGGATAAAGCTTGGGAGGAGATAAACAGGGGCGGA ATTATTAAAGTTCCCAGAATTTATTATTACGTAATGAGGTATATAACCCCCGCTTTCCTC GCGGTGCTCCTCGTTGTGTGGGCACGGGAGTACATACCGAAGATCATGGAAGAGACCCAC TGGACCGTGTGGATAACACGCTTTTACATAATAGGGCTTTTCCTCTTCCTCACTTTCCTC GTTTTCTTAGCTGAACGGAGAAGAAACCATGAGAGTGCTTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID O67854 UniProtKB Entry Name O67854_AQUAE GenBank Protein ID 2982776 GenBank Gene ID AE000657 PDB ID(s) 2A65, 2Q6H, 2Q72, 2QB4, 2QEI, 2QJU, 3F3A, 3F3C, 3F3D, 3F3E, 3F48, 3F4I, 3F4J, 3GJC, 3GJD, 3GWU, 3GWV, 3GWW, 3MPN, 3MPQ, 3QS4, 3QS5, 3QS6, 3TT1, 3TT3, 3TU0, 3USG, 3USI, 3USJ, 3USK, 3USL, 3USM, 3USO, 3USP, 4FXZ, 4FY0, 4HMK, 4HOD, 4MM4, 4MM5, 4MM6, 4MM7, 4MM8, 4MM9, 4MMA, 4MMB, 4MMC, 4MMD, 4MME, 4MMF KEGG ID aae:aq_2077 NCBI Gene ID 1193843 - General References
- Deckert G, Warren PV, Gaasterland T, Young WG, Lenox AL, Graham DE, Overbeek R, Snead MA, Keller M, Aujay M, Huber R, Feldman RA, Short JM, Olsen GJ, Swanson RV: The complete genome of the hyperthermophilic bacterium Aquifex aeolicus. Nature. 1998 Mar 26;392(6674):353-8. [Article]
- Yamashita A, Singh SK, Kawate T, Jin Y, Gouaux E: Crystal structure of a bacterial homologue of Na+/Cl--dependent neurotransmitter transporters. Nature. 2005 Sep 8;437(7056):215-23. Epub 2005 Jul 24. [Article]
- Singh SK, Yamashita A, Gouaux E: Antidepressant binding site in a bacterial homologue of neurotransmitter transporters. Nature. 2007 Aug 23;448(7156):952-6. Epub 2007 Aug 8. [Article]
- Zhou Z, Zhen J, Karpowich NK, Goetz RM, Law CJ, Reith ME, Wang DN: LeuT-desipramine structure reveals how antidepressants block neurotransmitter reuptake. Science. 2007 Sep 7;317(5843):1390-3. Epub 2007 Aug 9. [Article]
- Singh SK, Piscitelli CL, Yamashita A, Gouaux E: A competitive inhibitor traps LeuT in an open-to-out conformation. Science. 2008 Dec 12;322(5908):1655-61. doi: 10.1126/science.1166777. [Article]
- Zhou Z, Zhen J, Karpowich NK, Law CJ, Reith ME, Wang DN: Antidepressant specificity of serotonin transporter suggested by three LeuT-SSRI structures. Nat Struct Mol Biol. 2009 Jun;16(6):652-7. doi: 10.1038/nsmb.1602. Epub 2009 May 10. [Article]
- Quick M, Winther AM, Shi L, Nissen P, Weinstein H, Javitch JA: Binding of an octylglucoside detergent molecule in the second substrate (S2) site of LeuT establishes an inhibitor-bound conformation. Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):5563-8. doi: 10.1073/pnas.0811322106. Epub 2009 Mar 23. [Article]
- Kroncke BM, Horanyi PS, Columbus L: Structural origins of nitroxide side chain dynamics on membrane protein alpha-helical sites. Biochemistry. 2010 Nov 30;49(47):10045-60. doi: 10.1021/bi101148w. Epub 2010 Nov 8. [Article]
- Piscitelli CL, Gouaux E: Insights into transport mechanism from LeuT engineered to transport tryptophan. EMBO J. 2012 Jan 4;31(1):228-35. doi: 10.1038/emboj.2011.353. Epub 2011 Sep 27. [Article]
- Wang H, Gouaux E: Substrate binds in the S1 site of the F253A mutant of LeuT, a neurotransmitter sodium symporter homologue. EMBO Rep. 2012 Sep;13(9):861-6. doi: 10.1038/embor.2012.110. Epub 2012 Jul 27. [Article]
- Wang H, Elferich J, Gouaux E: Structures of LeuT in bicelles define conformation and substrate binding in a membrane-like context. Nat Struct Mol Biol. 2012 Jan 15;19(2):212-9. doi: 10.1038/nsmb.2215. [Article]
- Krishnamurthy H, Gouaux E: X-ray structures of LeuT in substrate-free outward-open and apo inward-open states. Nature. 2012 Jan 9;481(7382):469-74. doi: 10.1038/nature10737. [Article]
- Wang H, Goehring A, Wang KH, Penmatsa A, Ressler R, Gouaux E: Structural basis for action by diverse antidepressants on biogenic amine transporters. Nature. 2013 Nov 7;503(7474):141-5. doi: 10.1038/nature12648. Epub 2013 Oct 13. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details (R)-Fluoxetine experimental unknown target Details (S)-Fluoxetine experimental unknown target Details