2'-hydroxybiphenyl-2-sulfinate desulfinase
Details
- Name
- 2'-hydroxybiphenyl-2-sulfinate desulfinase
- Kind
- protein
- Synonyms
- 3.13.1.3
- Dibenzothiophene desulfurization enzyme B
- dszB
- Gene Name
- soxB
- UniProtKB Entry
- P54997Swiss-Prot
- Organism
- Rhodococcus sp. (strain IGTS8)
- NCBI Taxonomy ID
- 54064
- Amino acid sequence
>lcl|BSEQ0017278|2'-hydroxybiphenyl-2-sulfinate desulfinase MTSRVDPANPGSELDSAIRDTLTYSNCPVPNALLTASESGFLDAAGIELDVLSGQQGTVH FTYDQPAYTRFGGEIPPLLSEGLRAPGRTRLLGITPLLGRQGFFVRDDSPITAAADLAGR RIGVSASAIRILRGQLGDYLELDPWRQTLVALGSWEARALLHTLEHGELGVDDVELVPIS SPGVDVPAEQLEESATVKGADLFPDVARGQAAVLASGDVDALYSWLPWAGELQATGARPV VDLGLDERNAYASVWTVSSGLVRQRPGLVQRLVDAAVDAGLWARDHSDAVTSLHAANLGV STGAVGQGFGADFQQRLVPRLDHDALALLERTQQFLLTNNLLQEPVALDQWAAPEFLNNS LNRHR
- Number of residues
- 365
- Molecular Weight
- 39044.33
- Theoretical pI
- 4.44
- GO Classification
- Functions2'-hydroxybiphenyl-2-sulfinate desulfinase activity / monooxygenase activityProcessesdibenzothiophene catabolic process
- General Function
- Catalyzes the third and final step of the '4S' desulfurization pathway that removes covalently bound sulfur from dibenzothiophene (DBT) without breaking carbon-carbon bonds. Oxidizes 2-(2'-hydroxyphenyl)benzene sulphinate (HBPS) to 2-hydroxybiphenyl (HBP) plus sulfite (PubMed:31545606, PubMed:7574582, PubMed:7961424, PubMed:9308179, PubMed:9634856). The rate-limiting step of the '4S' desulfurization pathway (PubMed:31545606, PubMed:9308179). The pathway substrate specificity has been augmented using mutagenesis, however no mutations allowed use of alkylated thiophenes (PubMed:11823208).
- Specific Function
- 2'-hydroxybiphenyl-2-sulfinate desulfinase activity
- Pfam Domain Function
- Not Available
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0007567|1362 bp ATGACTCAACAACGACAAATGCATCTGGCCGGTTTCTTCTCGGCCGGCAATGTGACTCAT GCACATGGGGCGTGGCGGCACACGGACGCGTCGAATGACTTTCTGTCGGGGAAGTACTAC CAACACATCGCCCGTACTCTGGAGCGCGGCAAGTTCGATCTGTTGTTTCTGCCTGACGGG TTGGCCGTCGAGGACAGCTACGGGGACAACCTGGACACCGGTGTCGGCCTGGGCGGGCAG GGTGCAGTCGCCTTGGAGCCGGCCAGTGTGGTCGCAACCATGGCCGCGGTGACCGAGCAC CTGGGTCTTGGGGCAACCATTTCGGCGACCTACTATCCCCCGTATCACGTTGCTCGGGTG TTCGCGACGCTCGATCAGTTGTCAGGGGGTCGGGTGTCCTGGAACGTCGTCACCTCGCTC AACGACGCTGAAGCGCGCAACTTCGGCATTAATCAGCATCTGGAACACGACGCCCGCTAT GACCGCGCCGATGAGTTCTTGGAAGCGGTCAAGAAACTCTGGAACAGCTGGGACGAGGAC GCCCTCGTGCTGGACAAGGCGGCCGGCGTGTTCGCCGATCCCGCGAAGGTGCACTACGTC GATCACCACGGGGAGTGGCTGAATGTGCGCGGACCTCTGCAGGTACCGCGTTCACCTCAG GGTGAGCCGGTGATCCTGCAGGCCGGCCTGTCGCCCCGGGGTCGGCGCTTCGCCGGGAAG TGGGCCGAGGCCGTCTTCAGTCTTGCACCCAACCTCGAGGTGATGCAGGCCACCTACCAG GGCATCAAAGCCGAGGTCGACGCTGCGGGGCGCGATCCCGATCAGACGAAAATCTTCACC GCCGTGATGCCGGTACTCGGCGAAAGCCAGGCGGTGGCACAGGAACGACTGGAATATCTC AACAGTCTGGTCCATCCGGAAGTGGGACTGTCGACGCTATCCAGTCACACCGGCATCAAC CTGGCGGCGTACCCTCTCGACACTCCGATCAAGGACATCCTGCGGGATCTGCAGGATCGG AATGTCCCGACGCAACTGCACATGTTCGCCGCCGCAACGCACAGCGAAGAGCTCACGCTG GCGGAAATGGGTCGGCGCTATGGAACCAACGTGGGGTTCGTTCCTCAGTGGGCCGGTACC GGGGAGCAGATCGCTGACGAGCTGATCCGCCACTTCGAGGGCGGCGCCGCGGATGGTTTC ATCATCTCTCCGGCCTTCCTGCCGGGCTCCTACGACGAGTTCGTCGACCAGGTGGTTCCG GTTCTGCAGGATCGCGGCTACTTCCGCACCGAGTACCAGGGCAACACTCTGCGCGACCAC TTGGGTCTGCGCGTACCACAACTGCAAGGACAACCTTCATGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P54997 UniProtKB Entry Name SOXB_RHOSG GenBank Protein ID 595291 GenBank Gene ID U08850 PDB ID(s) 2DE2, 2DE3, 2DE4 - General References
- Denome SA, Oldfield C, Nash LJ, Young KD: Characterization of the desulfurization genes from Rhodococcus sp. strain IGTS8. J Bacteriol. 1994 Nov;176(21):6707-16. [Article]
- Piddington CS, Kovacevich BR, Rambosek J: Sequence and molecular characterization of a DNA region encoding the dibenzothiophene desulfurization operon of Rhodococcus sp. strain IGTS8. Appl Environ Microbiol. 1995 Feb;61(2):468-75. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details 1,1'-BIPHENYL-2-SULFINIC ACID experimental unknown target Details 2'-HYDROXY-1,1'-BIPHENYL-2-SULFINIC ACID experimental unknown target Details