2'-hydroxybiphenyl-2-sulfinate desulfinase

Details

Name
2'-hydroxybiphenyl-2-sulfinate desulfinase
Kind
protein
Synonyms
  • 3.13.1.3
  • Dibenzothiophene desulfurization enzyme B
  • dszB
Gene Name
soxB
UniProtKB Entry
P54997Swiss-Prot
Organism
Rhodococcus sp. (strain IGTS8)
NCBI Taxonomy ID
54064
Amino acid sequence
>lcl|BSEQ0017278|2'-hydroxybiphenyl-2-sulfinate desulfinase
MTSRVDPANPGSELDSAIRDTLTYSNCPVPNALLTASESGFLDAAGIELDVLSGQQGTVH
FTYDQPAYTRFGGEIPPLLSEGLRAPGRTRLLGITPLLGRQGFFVRDDSPITAAADLAGR
RIGVSASAIRILRGQLGDYLELDPWRQTLVALGSWEARALLHTLEHGELGVDDVELVPIS
SPGVDVPAEQLEESATVKGADLFPDVARGQAAVLASGDVDALYSWLPWAGELQATGARPV
VDLGLDERNAYASVWTVSSGLVRQRPGLVQRLVDAAVDAGLWARDHSDAVTSLHAANLGV
STGAVGQGFGADFQQRLVPRLDHDALALLERTQQFLLTNNLLQEPVALDQWAAPEFLNNS
LNRHR
Number of residues
365
Molecular Weight
39044.33
Theoretical pI
4.44
GO Classification
Functions
2'-hydroxybiphenyl-2-sulfinate desulfinase activity / monooxygenase activity
Processes
dibenzothiophene catabolic process
General Function
Catalyzes the third and final step of the '4S' desulfurization pathway that removes covalently bound sulfur from dibenzothiophene (DBT) without breaking carbon-carbon bonds. Oxidizes 2-(2'-hydroxyphenyl)benzene sulphinate (HBPS) to 2-hydroxybiphenyl (HBP) plus sulfite (PubMed:31545606, PubMed:7574582, PubMed:7961424, PubMed:9308179, PubMed:9634856). The rate-limiting step of the '4S' desulfurization pathway (PubMed:31545606, PubMed:9308179). The pathway substrate specificity has been augmented using mutagenesis, however no mutations allowed use of alkylated thiophenes (PubMed:11823208).
Specific Function
2'-hydroxybiphenyl-2-sulfinate desulfinase activity
Pfam Domain Function
Not Available
Signal Regions
Not Available
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0007567|1362 bp
ATGACTCAACAACGACAAATGCATCTGGCCGGTTTCTTCTCGGCCGGCAATGTGACTCAT
GCACATGGGGCGTGGCGGCACACGGACGCGTCGAATGACTTTCTGTCGGGGAAGTACTAC
CAACACATCGCCCGTACTCTGGAGCGCGGCAAGTTCGATCTGTTGTTTCTGCCTGACGGG
TTGGCCGTCGAGGACAGCTACGGGGACAACCTGGACACCGGTGTCGGCCTGGGCGGGCAG
GGTGCAGTCGCCTTGGAGCCGGCCAGTGTGGTCGCAACCATGGCCGCGGTGACCGAGCAC
CTGGGTCTTGGGGCAACCATTTCGGCGACCTACTATCCCCCGTATCACGTTGCTCGGGTG
TTCGCGACGCTCGATCAGTTGTCAGGGGGTCGGGTGTCCTGGAACGTCGTCACCTCGCTC
AACGACGCTGAAGCGCGCAACTTCGGCATTAATCAGCATCTGGAACACGACGCCCGCTAT
GACCGCGCCGATGAGTTCTTGGAAGCGGTCAAGAAACTCTGGAACAGCTGGGACGAGGAC
GCCCTCGTGCTGGACAAGGCGGCCGGCGTGTTCGCCGATCCCGCGAAGGTGCACTACGTC
GATCACCACGGGGAGTGGCTGAATGTGCGCGGACCTCTGCAGGTACCGCGTTCACCTCAG
GGTGAGCCGGTGATCCTGCAGGCCGGCCTGTCGCCCCGGGGTCGGCGCTTCGCCGGGAAG
TGGGCCGAGGCCGTCTTCAGTCTTGCACCCAACCTCGAGGTGATGCAGGCCACCTACCAG
GGCATCAAAGCCGAGGTCGACGCTGCGGGGCGCGATCCCGATCAGACGAAAATCTTCACC
GCCGTGATGCCGGTACTCGGCGAAAGCCAGGCGGTGGCACAGGAACGACTGGAATATCTC
AACAGTCTGGTCCATCCGGAAGTGGGACTGTCGACGCTATCCAGTCACACCGGCATCAAC
CTGGCGGCGTACCCTCTCGACACTCCGATCAAGGACATCCTGCGGGATCTGCAGGATCGG
AATGTCCCGACGCAACTGCACATGTTCGCCGCCGCAACGCACAGCGAAGAGCTCACGCTG
GCGGAAATGGGTCGGCGCTATGGAACCAACGTGGGGTTCGTTCCTCAGTGGGCCGGTACC
GGGGAGCAGATCGCTGACGAGCTGATCCGCCACTTCGAGGGCGGCGCCGCGGATGGTTTC
ATCATCTCTCCGGCCTTCCTGCCGGGCTCCTACGACGAGTTCGTCGACCAGGTGGTTCCG
GTTCTGCAGGATCGCGGCTACTTCCGCACCGAGTACCAGGGCAACACTCTGCGCGACCAC
TTGGGTCTGCGCGTACCACAACTGCAAGGACAACCTTCATGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP54997
UniProtKB Entry NameSOXB_RHOSG
GenBank Protein ID595291
GenBank Gene IDU08850
PDB ID(s)2DE2, 2DE3, 2DE4
General References
  1. Denome SA, Oldfield C, Nash LJ, Young KD: Characterization of the desulfurization genes from Rhodococcus sp. strain IGTS8. J Bacteriol. 1994 Nov;176(21):6707-16. [Article]
  2. Piddington CS, Kovacevich BR, Rambosek J: Sequence and molecular characterization of a DNA region encoding the dibenzothiophene desulfurization operon of Rhodococcus sp. strain IGTS8. Appl Environ Microbiol. 1995 Feb;61(2):468-75. [Article]

Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
1,1'-BIPHENYL-2-SULFINIC ACIDexperimentalunknowntargetDetails
2'-HYDROXY-1,1'-BIPHENYL-2-SULFINIC ACIDexperimentalunknowntargetDetails