Fumarate reductase iron-sulfur subunit

BE0003960ProteinEscherichia coli (strain K12)frdB

Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; fumarate reductase is used during anaerobic growth, and succinate dehydrogenase is used during aerobic growth. It is acted on by 2 drugs in DrugBank.

Gene name
frdB
UniProtKB entry
P0AC47Swiss-Prot
Residues / weight
244 residues · 27,123 Da
Also known as
1.3.5.1 · QFR iron-sulfur subunit · Quinol-fumarate reductase iron-sulfur subunit

Resolves to

Protein
UniProtP0AC47UniProt nameFRDB_ECOLI
Gene
NCBI Gene948666GenBank7019629
Pharmacology
KEGGecj:JW4114
Structure
PDB1KF6PDB1KFYPDB1L0V
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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16GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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11+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Fumarate reductase iron-sulfur subunit, and which indications are they being tested in?

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