Fumarate reductase subunit C

BE0003961ProteinEscherichia coli (strain K12)frdC

Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; fumarate reductase is used in anaerobic growth, and succinate dehydrogenase is used in aerobic growth. It is acted on by 2 drugs in DrugBank.

Gene name
frdC
UniProtKB entry
P0A8Q0Swiss-Prot
Cellular location
Cell inner membrane
Residues / weight
131 residues · 15,015 Da
Also known as
Fumarate reductase 15 kDa hydrophobic protein · QFR subunit C · Quinol-fumarate reductase subunit C

Resolves to

Protein
UniProtP0A8Q0UniProt nameFRDC_ECOLI
Gene
NCBI Gene948680GenBank7019629
Pharmacology
KEGGecj:JW4113
Structure
PDB1KF6PDB1KFYPDB1L0V
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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9GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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10+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Fumarate reductase subunit C, and which indications are they being tested in?

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