Fumarate reductase subunit D

BE0003962ProteinEscherichia coli (strain K12)frdD

Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; fumarate reductase is used in anaerobic growth, and succinate dehydrogenase is used in aerobic growth. It is acted on by 2 drugs in DrugBank.

Gene name
frdD
UniProtKB entry
P0A8Q3Swiss-Prot
Cellular location
Cell inner membrane
Residues / weight
119 residues · 13,107 Da
Also known as
Fumarate reductase 13 kDa hydrophobic protein · QFR subunit D · Quinol-fumarate reductase subunit D

Resolves to

Protein
UniProtP0A8Q3UniProt nameFRDD_ECOLI
Gene
NCBI Gene948668GenBank7019629
Pharmacology
KEGGecj:JW4112
Structure
PDB1KF6PDB1KFYPDB1L0V
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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12+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Fumarate reductase subunit D, and which indications are they being tested in?

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