Pyruvate carboxylase

BE0003966ProteinStaphylococcus aureus (strain Mu50 / ATCC 700699)pycA

Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. It is acted on by 1 drug in DrugBank.

Gene name
pycA
UniProtKB entry
A0A0H3JRU9TrEMBL
Residues / weight
1,150 residues · 128,557 Da
Also known as
6.4.1.1

Resolves to

Protein
UniProtA0A0H3JRU9UniProt namePYC_STAAM
Gene
GenBank14245768
Pharmacology
KEGGsav:SAV1114
Structure
PDB3BG5PDB3HB9PDB3HBL
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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6Pfam domainsDomain architecture mapped to Pfam families and clans
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5+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Pyruvate carboxylase, and which indications are they being tested in?

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