Porin P

Details

Name
Porin P
Kind
protein
Synonyms
  • Outer membrane protein D1
Gene Name
oprP
UniProtKB Entry
P05695Swiss-Prot
Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
NCBI Taxonomy ID
208964
Amino acid sequence
>lcl|BSEQ0012764|Porin P
MIRRHSCKGVGSSVAWSLLGLAISAQSLAGTVTTDGADIVIKTKGGLEVATTDKEFSFKL
GGRLQADYGRFDGYYTNNGNTADAAYFRRAYLEFGGTAYRDWKYQINYDLSRNVGNDSAG
YFDEASVTYTGFNPVNLKFGRFYTDFGLEKATSSKWVTALERNLTYDIADWVNDNVGTGI
QASSVVGGMAFLSGSVFSENNNDTDGDSVKRYNLRGVFAPLHEPGNVVHLGLQYAYRDLE
DSAVDTRIRPRMGMRGVSTNGGNDAGSNGNRGLFGGSSAVEGLWKDDSVWGLEGAWALGA
FSAQAEYLRRTVKAERDREDLKASGYYAQLAYTLTGEPRLYKLDGAKFDTIKPENKEIGA
WELFYRYDSIKVEDDNIVVDSATREVGDAKGKTHTLGVNWYANEAVKVSANYVKAKTDKI
SNANGDDSGDGLVMRLQYVF
Number of residues
440
Molecular Weight
48210.955
Theoretical pI
5.21
GO Classification
Functions
porin activity
Processes
ion transport
Components
cell outer membrane / pore complex
General Function
Anion specific, the binding site has higher affinity for phosphate than chloride ions. Porin O has a higher affinity for polyphosphates (tripolyphosphate and pyrophosphate) while porin P has a higher affinity for orthophosphate.
Specific Function
porin activity
Pfam Domain Function
Signal Regions
1-29
Transmembrane Regions
Not Available
Cellular Location
Cell outer membrane
Gene sequence
>lcl|BSEQ0012765|Porin P (oprP)
ATGATTCGCAGACACTCGTGCAAAGGGGTGGGGAGCAGTGTTGCCTGGAGTTTGCTGGGC
CTGGCGATTTCCGCGCAGAGCCTGGCCGGGACCGTGACCACCGACGGTGCCGACATCGTG
ATCAAGACCAAGGGCGGCCTCGAAGTCGCCACCACCGACAAGGAATTCAGCTTCAAGCTC
GGCGGCCGCCTGCAGGCCGACTACGGCCGCTTCGACGGCTACTACACGAACAACGGCAAT
ACCGCCGATGCCGCCTACTTCCGCCGCGCCTACCTGGAGTTCGGCGGCACCGCCTACCGG
GACTGGAAGTACCAGATCAACTACGACCTGTCGCGCAACGTCGGCAACGACAGCGCCGGC
TACTTTGACGAAGCTTCGGTCACCTATACCGGCTTCAACCCGGTCAACCTGAAGTTCGGC
CGCTTCTACACCGACTTCGGCCTGGAAAAGGCCACCAGCTCCAAATGGGTCACCGCGCTG
GAGCGCAACCTCACCTACGACATCGCCGACTGGGTCAACGACAACGTCGGTACCGGTATC
CAAGCCAGCTCGGTGGTGGGCGGCATGGCTTTCCTCTCTGGCAGCGTGTTCAGCGAGAAC
AACAACGATACCGACGGCGACAGCGTCAAGCGCTACAACCTGCGCGGCGTGTTCGCGCCG
CTGCACGAGCCGGGCAACGTGGTGCACCTGGGCCTGCAATACGCCTATCGCGACCTGGAG
GACAGCGCGGTGGATACCCGGATCCGCCCGCGCATGGGCATGCGCGGCGTCTCCACCAAT
GGCGGCAACGATGCCGGCAGCAATGGCAACCGCGGTCTGTTCGGCGGCAGTTCGGCAGTC
GAGGGGCTGTGGAAGGACGACTCGGTCTGGGGCCTGGAAGGCGCCTGGGCGCTGGGTGCC
TTCTCGGCCCAGGCCGAGTACCTGCGGCGCACGGTCAAGGCCGAGCGCGACCGCGAGGAT
CTCAAGGCCTCCGGCTATTACGCGCAACTGGCCTACACCCTCACCGGCGAGCCGCGCCTC
TACAAGCTGGACGGCGCCAAGTTCGACACCATCAAGCCGGAGAACAAGGAAATCGGCGCC
TGGGAGCTGTTCTACCGCTACGACTCGATCAAGGTCGAGGATGACAACATCGTCGTCGAC
AGCGCCACCCGCGAGGTCGGCGACGCCAAGGGCAAGACCCATACCCTGGGCGTCAACTGG
TACGCCAACGAGGCGGTGAAGGTTTCCGCCAACTACGTCAAGGCGAAGACCGACAAGATC
AGCAATGCCAACGGCGACGATAGCGGCGATGGCCTGGTGATGCGCCTGCAGTACGTGTTC
TGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP05695
UniProtKB Entry NamePORP_PSEAE
GenBank Protein ID45379
GenBank Gene IDX53313
PDB ID(s)2O4V
KEGG IDpae:PA3279
NCBI Gene ID882442
General References
  1. Siehnel R, Martin NL, Hancock RE: Sequence and relatedness in other bacteria of the Pseudomonas aeruginosa oprP gene coding for the phosphate-specific porin P. Mol Microbiol. 1990 May;4(5):831-8. [Article]
  2. Siehnel RJ, Egli C, Hancock RE: Polyphosphate-selective porin OprO of Pseudomonas aeruginosa: expression, purification and sequence. Mol Microbiol. 1992 Aug;6(16):2319-26. [Article]
  3. Stover CK, Pham XQ, Erwin AL, Mizoguchi SD, Warrener P, Hickey MJ, Brinkman FS, Hufnagle WO, Kowalik DJ, Lagrou M, Garber RL, Goltry L, Tolentino E, Westbrock-Wadman S, Yuan Y, Brody LL, Coulter SN, Folger KR, Kas A, Larbig K, Lim R, Smith K, Spencer D, Wong GK, Wu Z, Paulsen IT, Reizer J, Saier MH, Hancock RE, Lory S, Olson MV: Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen. Nature. 2000 Aug 31;406(6799):959-64. [Article]
  4. Siehnel RJ, Worobec EA, Hancock RE: Regulation of components of the Pseudomonas aeruginosa phosphate-starvation-inducible regulon in Escherichia coli. Mol Microbiol. 1988 May;2(3):347-52. [Article]
  5. Worobec EA, Martin NL, McCubbin WD, Kay CM, Brayer GD, Hancock RE: Large-scale purification and biochemical characterization of crystallization-grade porin protein P from Pseudomonas aeruginosa. Biochim Biophys Acta. 1988 Apr 7;939(2):366-74. [Article]
  6. Hancock RE, Benz R: Demonstration and chemical modification of a specific phosphate binding site in the phosphate-starvation-inducible outer membrane porin protein P of Pseudomonas aeruginosa. Biochim Biophys Acta. 1986 Sep 11;860(3):699-707. [Article]

Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
(Hydroxyethyloxy)Tri(Ethyloxy)OctaneexperimentalunknowntargetDetails