Replicase polyprotein 1a

BE0004014ProteinSARS-CoV

Isoform Replicase polyprotein 1a Multifunctional protein involved in the transcription and replication of viral RNAs. It is acted on by 4 drugs in DrugBank.

UniProtKB entry
P0C6U8Swiss-Prot
Cellular location
Host membrane
Residues / weight
4,382 residues · 486,369 Da
Also known as
ORF1a polyprotein · pp1a

Resolves to

Protein
UniProtP0C6U8UniProt nameR1A_SARS
Gene
NCBI Gene1489680GenBank30027621
Structure
PDB1P76PDB1P9TPDB1PA5
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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20GO termsFunction, process and component, as structured annotations
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13Pfam domainsDomain architecture mapped to Pfam families and clans
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31+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Replicase polyprotein 1a, how selective are they, and which programs against it are still in active trials?

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