Sulfide-quinone reductase
Details
- Name
- Sulfide-quinone reductase
- Kind
- protein
- Synonyms
- 1.8.5.4
- SQR
- Sulfide:quinone oxidoreductase
- Gene Name
- Not Available
- UniProtKB Entry
- B7JBP8Swiss-Prot
- Organism
- Acidithiobacillus ferrooxidans (strain ATCC 23270 / DSM 14882 / CIP 104768 / NCIMB 8455)
- NCBI Taxonomy ID
- 243159
- Amino acid sequence
>lcl|BSEQ0017301|Sulfide-quinone reductase MAHVVILGAGTGGMPAAYEMKEALGSGHEVTLISANDYFQFVPSNPWVGVGWKERDDIAF PIRHYVERKGIHFIAQSAEQIDAEAQNITLADGNTVHYDYLMIATGPKLAFENVPGSDPH EGPVQSICTVDHAERAFAEYQALLREPGPIVIGAMAGASCFGPAYEYAMIVASDLKKRGM RDKIPSFTFITSEPYIGHLGIQGVGDSKGILTKGLKEEGIEAYTNCKVTKVEDNKMYVTQ VDEKGETIKEMVLPVKFGMMIPAFKGVPAVAGVEGLCNPGGFVLVDEHQRSKKYANIFAA GIAIAIPPVETTPVPTGAPKTGYMIESMVSAAVHNIKADLEGRKGEQTMGTWNAVCFADM GDRGAAFIALPQLKPRKVDVFAYGRWVHLAKVAFEKYFIRKMKMGVSEPFYEKVLFKMMG ITRLKEEDTHRKAS
- Number of residues
- 434
- Molecular Weight
- 47405.465
- Theoretical pI
- 6.8
- GO Classification
- Functionsnucleotide binding / oxidoreductase activity / quinone bindingComponentsmembrane
- General Function
- Catalyzes the oxidation of hydrogen sulfide, with the help of a quinone. Consecutive reaction cycles lead to the accumulation of a polysulfide product on the active site Cys residues; these products are released when they exceed a critical length, typically as cyclooctasulfur.
- Specific Function
- nucleotide binding
- Pfam Domain Function
- Pyr_redox_2 (PF07992)
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Membrane
- Gene sequence
>lcl|BSEQ0017302|Sulfide-quinone reductase ATGGCACATGTGGTAATTTTGGGTGCGGGCACAGGCGGAATGCCGGCGGCCTACGAAATG AAGGAAGCTCTGGGTTCTGGGCATGAGGTGACGCTGATCAGCGCCAATGATTATTTCCAG TTCGTTCCGTCCAACCCGTGGGTGGGGGTGGGCTGGAAGGAGCGCGATGATATCGCTTTC CCAATCCGGCACTATGTGGAACGTAAAGGAATACATTTTATCGCGCAGTCCGCCGAACAG ATCGATGCCGAAGCGCAGAATATCACCCTTGCCGACGGCAACACGGTACATTACGACTAC CTGATGATCGCGACAGGTCCGAAGCTGGCTTTCGAGAATGTACCGGGTTCCGATCCCCAT GAAGGCCCGGTGCAGTCCATTTGTACGGTGGACCATGCGGAACGGGCCTTTGCCGAATAC CAGGCTTTGTTGCGCGAGCCCGGCCCCATTGTCATCGGTGCCATGGCCGGCGCAAGTTGC TTCGGACCGGCTTACGAATATGCCATGATCGTCGCTTCCGACCTCAAAAAACGGGGCATG CGCGACAAGATTCCGTCCTTCACCTTTATCACCAGTGAGCCCTACATCGGTCATCTGGGC ATTCAGGGCGTGGGCGATTCCAAGGGCATTCTGACGAAGGGCCTCAAGGAAGAAGGTATC GAAGCGTACACGAACTGTAAGGTCACCAAGGTCGAAGACAACAAGATGTATGTAACCCAG GTGGACGAGAAGGGTGAAACCATCAAGGAGATGGTTCTGCCGGTCAAGTTCGGGATGATG ATCCCGGCTTTCAAGGGCGTGCCAGCGGTGGCGGGTGTCGAAGGATTGTGCAATCCCGGT GGCTTCGTGCTGGTGGATGAGCACCAGCGCAGCAAGAAATACGCAAATATCTTTGCGGCG GGTATCGCCATCGCCATTCCGCCGGTAGAGACGACCCCGGTGCCGACCGGCGCGCCCAAG ACCGGTTATATGATCGAATCCATGGTGTCGGCGGCGGTGCACAACATCAAGGCGGATCTG GAAGGCCGCAAGGGCGAGCAGACCATGGGCACCTGGAATGCGGTGTGTTTTGCCGATATG GGTGATCGCGGCGCGGCATTTATCGCCTTGCCCCAGTTGAAGCCCCGTAAAGTGGACGTC TTTGCCTACGGGCGCTGGGTGCATCTGGCGAAGGTGGCCTTTGAAAAATACTTTATCCGC AAAATGAAGATGGGTGTCTCCGAGCCCTTCTATGAGAAGGTGCTGTTCAAGATGATGGGC ATTACCCGTCTGAAGGAAGAAGATACCCATCGTAAGGCCTCCTGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID B7JBP8 UniProtKB Entry Name SQRD_ACIF2 GenBank Protein ID 218519790 GenBank Gene ID CP001219 PDB ID(s) 3KPK, 3SX6, 3SXI, 3SY4, 3SYI, 3SZ0, 3SZC, 3SZF, 3SZW, 3T0K, 3T14, 3T2K, 3T2Y, 3T2Z, 3T31 KEGG ID afr:AFE_1792 - General References
- Valdes J, Pedroso I, Quatrini R, Dodson RJ, Tettelin H, Blake R 2nd, Eisen JA, Holmes DS: Acidithiobacillus ferrooxidans metabolism: from genome sequence to industrial applications. BMC Genomics. 2008 Dec 11;9:597. doi: 10.1186/1471-2164-9-597. [Article]
- Cherney MM, Zhang Y, Solomonson M, Weiner JH, James MN: Crystal structure of sulfide:quinone oxidoreductase from Acidithiobacillus ferrooxidans: insights into sulfidotrophic respiration and detoxification. J Mol Biol. 2010 Apr 30;398(2):292-305. doi: 10.1016/j.jmb.2010.03.018. Epub 2010 Mar 19. [Article]
- Cherney MM, Zhang Y, James MN, Weiner JH: Structure-activity characterization of sulfide:quinone oxidoreductase variants. J Struct Biol. 2012 Jun;178(3):319-28. doi: 10.1016/j.jsb.2012.04.007. Epub 2012 Apr 19. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details 2-decyl-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione experimental unknown target Details