Ribonuclease H

Details

Name
Ribonuclease H
Kind
protein
Synonyms
  • 3.1.26.4
  • RNase H
Gene Name
rnhA
UniProtKB Entry
Q9KEI9Swiss-Prot
Organism
Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
NCBI Taxonomy ID
272558
Amino acid sequence
>lcl|BSEQ0017305|Ribonuclease H
MAKSKYYVVWNGRKPGIYTSWSACEAQVKGYTGAKFKSYPSKEEAEAAFRGEEATPKLAK
EEIIWESLSVDVGSQGNPGIVEYKGVDTKTGEVLFEREPIPIGTNNMGEFLAIVHGLRYL
KERNSRKPIYSDSQTAIKWVKDKKAKSTLVRNEETALIWKLVDEAEEWLNTHTYETPILK
WQTDKWGEIKADYGRK
Number of residues
196
Molecular Weight
22373.225
Theoretical pI
8.81
GO Classification
Functions
metal ion binding / nucleic acid binding / RNA-DNA hybrid ribonuclease activity
Components
cytoplasm
General Function
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
Specific Function
metal ion binding
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0017306|Ribonuclease H (rnhA)
ATGGCAAAGTCAAAATACTATGTCGTATGGAATGGACGGAAGCCCGGCATTTATACGAGC
TGGTCTGCATGTGAAGCTCAAGTAAAAGGATATACCGGCGCCAAATTTAAATCCTATCCT
TCCAAGGAAGAAGCAGAGGCTGCTTTTAGAGGAGAAGAGGCAACACCGAAGCTTGCAAAA
GAGGAGATTATTTGGGAGAGCCTGTCTGTAGATGTTGGCAGCCAAGGGAATCCCGGAATT
GTGGAATATAAAGGCGTTGATACGAAAACGGGAGAAGTCCTTTTTGAACGAGAGCCGATT
CCGATCGGGACAAACAATATGGGTGAGTTTCTCGCGATCGTTCACGGGCTTCGTTACCTT
AAGGAACGGAACAGTCGTAAGCCGATCTATTCTGATTCCCAGACGGCAATCAAATGGGTG
AAGGATAAAAAAGCAAAATCGACCCTCGTGCGCAATGAAGAAACAGCGCTTATTTGGAAG
CTTGTAGATGAAGCGGAGGAGTGGCTAAACACTCATACATATGAAACGCCCATCTTAAAA
TGGCAGACCGATAAGTGGGGGGAAATTAAGGCCGATTACGGGAGAAAATAA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDQ9KEI9
UniProtKB Entry NameRNH1_BACHD
GenBank Protein ID10172613
GenBank Gene IDBA000004
PDB ID(s)1ZBF, 1ZBI, 1ZBL, 2G8F, 2G8H, 2G8I, 2G8K, 2G8U, 2G8V, 2G8W, 2R7Y, 3D0P, 3EY1, 3I8D, 3TWH, 3ULD, 4HTU, 4HUE, 4HUF, 4HUG, 4OPJ, 4OPK
KEGG IDbha:BH0863
General References
  1. Takami H, Nakasone K, Takaki Y, Maeno G, Sasaki R, Masui N, Fuji F, Hirama C, Nakamura Y, Ogasawara N, Kuhara S, Horikoshi K: Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans and genomic sequence comparison with Bacillus subtilis. Nucleic Acids Res. 2000 Nov 1;28(21):4317-31. [Article]
  2. Nowotny M, Gaidamakov SA, Crouch RJ, Yang W: Crystal structures of RNase H bound to an RNA/DNA hybrid: substrate specificity and metal-dependent catalysis. Cell. 2005 Jul 1;121(7):1005-16. [Article]

Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
1-[2-DEOXYRIBOFURANOSYL]-2,4-DIFLUORO-5-METHYL-BENZENE-5'MONOPHOSPHATEexperimentalunknowntargetDetails