Ribonuclease H
Details
- Name
- Ribonuclease H
- Kind
- protein
- Synonyms
- 3.1.26.4
- RNase H
- Gene Name
- rnhA
- UniProtKB Entry
- Q9KEI9Swiss-Prot
- Organism
- Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
- NCBI Taxonomy ID
- 272558
- Amino acid sequence
>lcl|BSEQ0017305|Ribonuclease H MAKSKYYVVWNGRKPGIYTSWSACEAQVKGYTGAKFKSYPSKEEAEAAFRGEEATPKLAK EEIIWESLSVDVGSQGNPGIVEYKGVDTKTGEVLFEREPIPIGTNNMGEFLAIVHGLRYL KERNSRKPIYSDSQTAIKWVKDKKAKSTLVRNEETALIWKLVDEAEEWLNTHTYETPILK WQTDKWGEIKADYGRK
- Number of residues
- 196
- Molecular Weight
- 22373.225
- Theoretical pI
- 8.81
- GO Classification
- Functionsmetal ion binding / nucleic acid binding / RNA-DNA hybrid ribonuclease activityComponentscytoplasm
- General Function
- Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
- Specific Function
- metal ion binding
- Pfam Domain Function
- Cauli_VI (PF01693)
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0017306|Ribonuclease H (rnhA) ATGGCAAAGTCAAAATACTATGTCGTATGGAATGGACGGAAGCCCGGCATTTATACGAGC TGGTCTGCATGTGAAGCTCAAGTAAAAGGATATACCGGCGCCAAATTTAAATCCTATCCT TCCAAGGAAGAAGCAGAGGCTGCTTTTAGAGGAGAAGAGGCAACACCGAAGCTTGCAAAA GAGGAGATTATTTGGGAGAGCCTGTCTGTAGATGTTGGCAGCCAAGGGAATCCCGGAATT GTGGAATATAAAGGCGTTGATACGAAAACGGGAGAAGTCCTTTTTGAACGAGAGCCGATT CCGATCGGGACAAACAATATGGGTGAGTTTCTCGCGATCGTTCACGGGCTTCGTTACCTT AAGGAACGGAACAGTCGTAAGCCGATCTATTCTGATTCCCAGACGGCAATCAAATGGGTG AAGGATAAAAAAGCAAAATCGACCCTCGTGCGCAATGAAGAAACAGCGCTTATTTGGAAG CTTGTAGATGAAGCGGAGGAGTGGCTAAACACTCATACATATGAAACGCCCATCTTAAAA TGGCAGACCGATAAGTGGGGGGAAATTAAGGCCGATTACGGGAGAAAATAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q9KEI9 UniProtKB Entry Name RNH1_BACHD GenBank Protein ID 10172613 GenBank Gene ID BA000004 PDB ID(s) 1ZBF, 1ZBI, 1ZBL, 2G8F, 2G8H, 2G8I, 2G8K, 2G8U, 2G8V, 2G8W, 2R7Y, 3D0P, 3EY1, 3I8D, 3TWH, 3ULD, 4HTU, 4HUE, 4HUF, 4HUG, 4OPJ, 4OPK KEGG ID bha:BH0863 - General References
- Takami H, Nakasone K, Takaki Y, Maeno G, Sasaki R, Masui N, Fuji F, Hirama C, Nakamura Y, Ogasawara N, Kuhara S, Horikoshi K: Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans and genomic sequence comparison with Bacillus subtilis. Nucleic Acids Res. 2000 Nov 1;28(21):4317-31. [Article]
- Nowotny M, Gaidamakov SA, Crouch RJ, Yang W: Crystal structures of RNase H bound to an RNA/DNA hybrid: substrate specificity and metal-dependent catalysis. Cell. 2005 Jul 1;121(7):1005-16. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details 1-[2-DEOXYRIBOFURANOSYL]-2,4-DIFLUORO-5-METHYL-BENZENE-5'MONOPHOSPHATE experimental unknown target Details