Isopentenyl-diphosphate Delta-isomerase 1

BE0004044ProteinHumansIDI1

Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). It is acted on by 1 drug in DrugBank.

Gene name
IDI1
UniProtKB entry
Q13907Swiss-Prot
Cellular location
Peroxisome
Residues / weight
227 residues · 26,319 Da
Also known as
5.3.3.2 · IPP isomerase 1 · IPPI1 · Isopentenyl pyrophosphate isomerase 1

Resolves to

Protein
UniProtQ13907UniProt nameIDI1_HUMAN
Gene
HGNCHGNC:5387NCBI Gene3422GenBank488750GeneCardsIDI1
Pharmacology
IUPHAR/GtoPdb646KEGGhsa:3422
Structure
PDB2DHOPDB2I6KPDB2ICJ
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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11+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Isopentenyl-diphosphate Delta-isomerase 1, and which indications are they being tested in?

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