4-hydroxy-3-methylbut-2-enyl diphosphate reductase

BE0004045ProteinEscherichia coli (strain K12)ispH

Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). It is acted on by 2 drugs in DrugBank.

Gene name
ispH
UniProtKB entry
P62623Swiss-Prot
Residues / weight
316 residues · 34,774 Da
Also known as
1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase · 1.17.1.2 · 1.17.7.4 · HMBPP reductase · lytB

Resolves to

Protein
UniProtP62623UniProt nameISPH_ECOLI
Gene
NCBI Gene944777GenBank18652795
Pharmacology
KEGGecj:JW0027
Structure
PDB3F7TPDB3KE8PDB3KE9
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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17+ReferencesStructured and connected to the statements they support
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Which compounds in development act on 4-hydroxy-3-methylbut-2-enyl diphosphate reductase, and which indications are they being tested in?

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