Dethiobiotin synthetase BioD

BE0004052ProteinMycobacterium tuberculosisbioD

Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring (PubMed:20565114). It is acted on by 1 drug in DrugBank.

Gene name
bioD
UniProtKB entry
P9WPQ5Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
226 residues · 22,456 Da
Also known as
6.3.3.3 · ATP-dependent dethiobiotin synthetase BioD · Dethiobiotin synthase · DTB synthetase · DTBS

Resolves to

Protein
UniProtP9WPQ5UniProt nameBIOD_MYCTU
Gene
NCBI Gene886338
Pharmacology
KEGGmtu:Rv1570
Structure
PDB3FGNPDB3FMFPDB3FMI
Drugs

What you can answer from here — as of May 03, 2025

1DrugApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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4+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Dethiobiotin synthetase BioD, and which indications are they being tested in?

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