MAP kinase-activated protein kinase 3

BE0004064ProteinHumansMAPKAPK3

Stress-activated serine/threonine-protein kinase involved in cytokines production, endocytosis, cell migration, chromatin remodeling and transcriptional regulation. It is acted on by 2 drugs in DrugBank.

Gene name
MAPKAPK3
UniProtKB entry
Q16644Swiss-Prot
Cellular location
Nucleus
Residues / weight
382 residues · 42,987 Da
Also known as
2.7.11.1 · 3pK · Chromosome 3p kinase · MAPK-activated protein kinase 3 · MAPKAP kinase 3

Resolves to

Protein
UniProtQ16644UniProt nameMAPK3_HUMAN
Gene
HGNCHGNC:6888NCBI Gene7867GenBank1256005GeneCardsMAPKAPK3
Pharmacology
IUPHAR/GtoPdb2095KEGGhsa:7867
Structure
PDB3FHRPDB3FXWPDB3R1N
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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24+ReferencesStructured and connected to the statements they support
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Which compounds in development act on MAP kinase-activated protein kinase 3, and which indications are they being tested in?

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