Hydroxymethylglutaryl-CoA synthase, cytoplasmic

BE0004067ProteinHumansHMGCS1

Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate, a precursor for cholesterol synthesis. It is acted on by 1 drug in DrugBank.

Gene name
HMGCS1
UniProtKB entry
Q01581Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
520 residues · 57,293 Da
Also known as
2.3.3.10 · 3-hydroxy-3-methylglutaryl coenzyme A synthase · HMG-CoA synthase · HMGCS

Resolves to

Protein
UniProtQ01581UniProt nameHMCS1_HUMAN
Gene
HGNCHGNC:5007NCBI Gene3157GenBank30009GeneCardsHMGCS1
Pharmacology
IUPHAR/GtoPdb638KEGGhsa:3157
Structure
PDB2P8U
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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10GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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13+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Hydroxymethylglutaryl-CoA synthase, cytoplasmic, and which indications are they being tested in?

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