Geranylgeranyl transferase type-2 subunit alpha

BE0004072ProteinHumansRABGGTA

Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A. It is acted on by 3 drugs in DrugBank.

Gene name
RABGGTA
UniProtKB entry
Q92696Swiss-Prot
Residues / weight
567 residues · 65,071 Da
Also known as
2.5.1.60 · Geranylgeranyl transferase type II subunit alpha · Rab geranyl-geranyltransferase subunit alpha · Rab geranylgeranyltransferase subunit alpha · Rab GG transferase alpha

Resolves to

Protein
UniProtQ92696UniProt namePGTA_HUMAN
Gene
HGNCHGNC:9795NCBI Gene5875GenBank2950170GeneCardsRABGGTA
Pharmacology
KEGGhsa:5875
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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10+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Geranylgeranyl transferase type-2 subunit alpha, and which indications are they being tested in?

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