Geranylgeranyl transferase type-2 subunit beta

BE0004073ProteinHumansRABGGTB

Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A (PubMed:7991565). It is acted on by 3 drugs in DrugBank.

Gene name
RABGGTB
UniProtKB entry
P53611Swiss-Prot
Residues / weight
331 residues · 36,924 Da
Also known as
2.5.1.60 · Geranylgeranyl transferase type II subunit beta · GGTase-II-beta · GGTB · Rab geranyl-geranyltransferase subunit beta

Resolves to

Protein
UniProtP53611UniProt namePGTB2_HUMAN
Gene
HGNCHGNC:9796NCBI Gene5876GenBank1216504GeneCardsRABGGTB
Pharmacology
KEGGhsa:5876
Structure
PDB6J6XPDB6J74PDB6J7F
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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14+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Geranylgeranyl transferase type-2 subunit beta, and which indications are they being tested in?

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