(2Z,6E)-farnesyl diphosphate synthase

BE0004093ProteinMycobacterium tuberculosis

Catalyzes the condensation of only one isopentenyl pyrophosphate (IPP) unit in the cis configuration to E-geranyl diphosphate (E-GPP) generating the 15 carbon product (2Z,6E)-farnesyl diphosphate (Z-FPP or EZ-FPP). It is acted on by 2 drugs in DrugBank.

UniProtKB entry
P9WFF5Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
262 residues · 29,410 Da
Also known as
2.5.1.68 · Short-chain Z-isoprenyl diphosphate synthase · Z-FPP synthase · Z-FPPS · Z-isoprenyl diphosphate synthase

Resolves to

Protein
UniProtP9WFF5UniProt nameZFPP_MYCTU
Gene
NCBI Gene887097
Pharmacology
KEGGmtu:Rv1086
Structure
PDB2VFWPDB2VG0PDB2VG1
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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9+ReferencesStructured and connected to the statements they support
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Which compounds in development act on (2Z,6E)-farnesyl diphosphate synthase, and which indications are they being tested in?

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