Mevalonate kinase

BE0004094ProteinHumansMVK

Catalyzes the phosphorylation of mevalonate to mevalonate 5-phosphate, a key step in isoprenoid and cholesterol biosynthesis (PubMed:11278915, PubMed:18302342, PubMed:9325256, PubMed:9392419). It is acted on by 1 drug in DrugBank.

Gene name
MVK
UniProtKB entry
Q03426Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
396 residues · 42,450 Da
Also known as
2.7.1.36 · MK

Resolves to

Protein
UniProtQ03426UniProt nameKIME_HUMAN
Gene
HGNCHGNC:7530NCBI Gene4598GenBank187561GeneCardsMVK
Pharmacology
IUPHAR/GtoPdb640KEGGhsa:4598
Structure
PDB2R3V
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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13+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Mevalonate kinase, and which indications are they being tested in?

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