Platelet-activating factor acetylhydrolase IB subunit alpha1
Details
- Name
- Platelet-activating factor acetylhydrolase IB subunit alpha1
- Kind
- protein
- Synonyms
- 3.1.1.47
- PAF acetylhydrolase 29 kDa subunit
- PAF-AH 29 kDa subunit
- PAF-AH subunit gamma
- PAFAH subunit gamma
- PAFAHG
- Gene Name
- PAFAH1B3
- UniProtKB Entry
- Q15102Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0012858|Platelet-activating factor acetylhydrolase IB subunit alpha1 MSGEENPASKPTPVQDVQGDGRWMSLHHRFVADSKDKEPEVVFIGDSLVQLMHQCEIWRE LFSPLHALNFGIGGDGTQHVLWRLENGELEHIRPKIVVVWVGTNNHGHTAEQVTGGIKAI VQLVNERQPQARVVVLGLLPRGQHPNPLREKNRQVNELVRAALAGHPRAHFLDADPGFVH SDGTISHHDMYDYLHLSRLGYTPVCRALHSLLLRLLAQDQGQGAPLLEPAP
- Number of residues
- 231
- Molecular Weight
- 25734.13
- Theoretical pI
- 6.84
- GO Classification
- Functions1-alkyl-2-acetylglycerophosphocholine esterase activity / identical protein binding / platelet-activating factor acetyltransferase activityProcesseslipid catabolic process / lipid metabolic process / nervous system development / spermatogenesisComponentscytoplasm / cytosol / membrane
- General Function
- Alpha1 catalytic subunit of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)) heterotetrameric enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and modulates the action of PAF. The activity and substrate specificity of PAF-AH (I) are affected by its subunit composition. Both alpha1/alpha1 homodimer (PAFAH1B3/PAFAH1B3 homodimer) and alpha1/alpha2 heterodimer(PAFAH1B3/PAFAH1B2 heterodimer) hydrolyze 1-O-alkyl-2-acetyl-sn-glycero-3-phosphoric acid (AAGPA) more efficiently than PAF, but they have little hydrolytic activity towards 1-O-alkyl-2-acetyl-sn-glycero-3-phosphorylethanolamine (AAGPE). Plays an important role during the development of brain
- Specific Function
- 1-alkyl-2-acetylglycerophosphocholine esterase activity
- Pfam Domain Function
- Lipase_GDSL_2 (PF13472)
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0012859|Platelet-activating factor acetylhydrolase IB subunit gamma (PAFAH1B3) ATGAGTGGAGAGGAGAACCCAGCCAGCAAGCCCACGCCGGTGCAGGACGTACAGGGCGAC GGGCGCTGGATGTCCCTGCACCATCGGTTCGTGGCTGACAGCAAAGATAAGGAACCCGAA GTCGTCTTCATCGGGGACTCCTTGGTCCAGCTCATGCACCAGTGCGAGATCTGGCGCGAG CTCTTCTCTCCTCTGCATGCACTTAACTTTGGCATTGGTGGTGACGGCACACAGCATGTA CTGTGGCGGCTGGAGAATGGGGAGCTGGAACACATCCGGCCCAAGATTGTGGTGGTCTGG GTGGGCACCAACAACCACGGACACACAGCAGAGCAGGTGACTGGTGGCATCAAGGCCATT GTGCAACTGGTGAATGAGCGACAGCCCCAGGCCCGGGTTGTGGTGCTGGGCCTGCTTCCG CGAGGCCAACATCCCAACCCACTTCGGGAGAAGAACCGACAGGTGAACGAGCTGGTACGG GCGGCACTGGCTGGCCACCCTCGGGCCCACTTCCTAGATGCCGACCCTGGCTTTGTGCAC TCAGATGGCACCATCAGCCATCATGACATGTATGATTACCTGCATCTGAGCCGCCTGGGC TACACACCTGTTTGCCGGGCTCTGCACTCCCTGCTTCTGCGTCTGCTGGCCCAAGACCAG GGCCAAGGTGCTCCCCTGCTGGAGCCCGCACCCTAA
- Chromosome Location
- 19
- Locus
- 19q13.2
- External Identifiers
Resource Link UniProtKB ID Q15102 UniProtKB Entry Name PA1B3_HUMAN GenBank Protein ID 1122219 GenBank Gene ID D63391 GeneCard ID PAFAH1B3 HGNC ID HGNC:8576 KEGG ID hsa:5050 NCBI Gene ID 5050 - General References
- Adachi H, Tsujimoto M, Hattori M, Arai H, Inoue K: cDNA cloning of human cytosolic platelet-activating factor acetylhydrolase gamma-subunit and its mRNA expression in human tissues. Biochem Biophys Res Commun. 1995 Sep 5;214(1):180-7. [Article]
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Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details (1R)-1,2,2-trimethylpropyl (R)-methylphosphinate experimental unknown target Details