Decaprenyl diphosphate synthase

BE0004107ProteinMycobacterium tuberculosisuppS

Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) in the cis configuration with (2Z,6E)-farnesyl diphosphate (Z-FPP or EZ-FPP) generating the 50 carbon product trans,polycis-decaprenyl diphosphate. It is acted on by 2 drugs in DrugBank.

Gene name
uppS
UniProtKB entry
P9WFF7Swiss-Prot
Cellular location
Cell membrane
Residues / weight
296 residues · 33,791 Da
Also known as
2.5.1.86 · DecaPP · Decaprenyl pyrophosphate synthase · Long-chain isoprenyl diphosphate synthase · Trans,polycis-decaprenyl diphosphate synthase

Resolves to

Protein
UniProtP9WFF7UniProt nameDPDS_MYCTU
Gene
NCBI Gene888964
Pharmacology
KEGGmtu:Rv2361c
Structure
PDB2VG2PDB2VG3PDB2VG4
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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10GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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8+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Decaprenyl diphosphate synthase, and which indications are they being tested in?

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