UDP-3-O-acyl-N-acetylglucosamine deacetylase

BE0004110ProteinPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)lpxC

Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis. It is acted on by 1 drug in DrugBank.

Gene name
lpxC
UniProtKB entry
P47205Swiss-Prot
Cellular location
Cytoplasmic
Residues / weight
303 residues · 33,435 Da
Also known as
3.5.1.- · 3.5.1.108 · envA · Protein EnvA · UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Resolves to

Protein
UniProtP47205UniProt nameLPXC_PSEAE
Gene
NCBI Gene881292GenBank6715617
Pharmacology
KEGGpae:PA4406
Structure
PDB2VESPDB3P3EPDB3U1Y
Drugs

What you can answer from here — as of May 03, 2025

1DrugApproved to experimental, with action, bond type and pharmacological action
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2GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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4+ReferencesStructured and connected to the statements they support
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Which compounds in development act on UDP-3-O-acyl-N-acetylglucosamine deacetylase, and which indications are they being tested in?

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