4-hydroxymandelate synthase

BE0004115ProteinAmycolatopsis orientalis

Required to synthesize hydroxyphenylglycine, a recurring skeletal component of nonproteinogenic macrocyclic peptide antibiotics such as vancomycin. It is acted on by 1 drug in DrugBank.

UniProtKB entry
O52791Swiss-Prot
Residues / weight
357 residues · 38,338 Da
Also known as
1.13.11.46 · 4-hydroxyphenylpyruvate dioxygenase II · HMS

Resolves to

Protein
UniProtO52791UniProt nameHMAS_AMYOR
Gene
GenBank2894184
Structure
PDB2R5V
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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4+ReferencesStructured and connected to the statements they support
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Which compounds in development act on 4-hydroxymandelate synthase, and which indications are they being tested in?

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