4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase

BE0004121ProteinMycobacterium tuberculosishsaD

Catalyzes the hydrolysis of a carbon-carbon bond in 4,5: 9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate (4,9-DSHA) to yield 9,17-dioxo-1,2,3,4,10,19-hexanorandrostan-5-oate (DOHNAA) and 2-hydroxy-hexa-2,4-dienoate (HHD). It is acted on by 1 drug in DrugBank.

Gene name
hsaD
UniProtKB entry
P9WNH5Swiss-Prot
Residues / weight
291 residues · 31,875 Da
Also known as
2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase · 3.7.1.17 · bphD · HOPDA hydrolase · MCP hydrolase

Resolves to

Protein
UniProtP9WNH5UniProt nameHSAD_MYCTU
Gene
NCBI Gene887378
Pharmacology
KEGGmtu:Rv3569c
Structure
PDB2VF2PDB2WUDPDB2WUE
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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9GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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7+ReferencesStructured and connected to the statements they support
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Which compounds in development act on 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase, and which indications are they being tested in?

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