Biotin biosynthesis cytochrome P450
Details
- Name
- Biotin biosynthesis cytochrome P450
- Kind
- protein
- Synonyms
- 1.14.15.12
- CYP107H
- Gene Name
- bioI
- UniProtKB Entry
- P53554Swiss-Prot
- Organism
- Bacillus subtilis (strain 168)
- NCBI Taxonomy ID
- 224308
- Amino acid sequence
>lcl|BSEQ0017336|Biotin biosynthesis cytochrome P450 MTIASSTASSEFLKNPYSFYDTLRAVHPIYKGSFLKYPGWYVTGYEETAAILKDARFKVR TPLPESSTKYQDLSHVQNQMMLFQNQPDHRRLRTLASGAFTPRTTESYQPYIIETVHHLL DQVQGKKKMEVISDFAFPLASFVIANIIGVPEEDREQLKEWAASLIQTIDFTRSRKALTE GNIMAVQAMAYFKELIQKRKRHPQQDMISMLLKGREKDKLTEEEAASTCILLAIAGHETT VNLISNSVLCLLQHPEQLLKLRENPDLIGTAVEECLRYESPTQMTARVASEDIDICGVTI RQGEQVYLLLGAANRDPSIFTNPDVFDITRSPNPHLSFGHGHHVCLGSSLARLEAQIAIN TLLQRMPSLNLADFEWRYRPLFGFRALEELPVTFE
- Number of residues
- 395
- Molecular Weight
- 44864.93
- Theoretical pI
- 6.65
- GO Classification
- Functionsheme binding / iron ion binding / monooxygenase activity / oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygenProcessesbiotin biosynthetic process
- General Function
- Catalyzes the C-C bond cleavage of fatty acid linked to acyl carrier protein (ACP) to generate pimelic acid for biotin biosynthesis. It has high affinity for long-chain fatty acids with the greatest affinity for myristic acid.
- Specific Function
- heme binding
- Pfam Domain Function
- p450 (PF00067)
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0017337|Biotin biosynthesis cytochrome P450 (bioI) GTGACAATTGCATCGTCAACTGCATCTTCTGAGTTTTTGAAAAACCCATATTCTTTTTAC GACACATTGCGAGCTGTTCATCCTATCTATAAAGGGAGTTTCTTAAAATACCCGGGCTGG TATGTCACAGGATATGAAGAAACGGCTGCTATTTTGAAAGATGCGAGATTCAAAGTCCGC ACCCCGCTGCCTGAGAGCTCAACCAAATATCAGGACCTTTCACATGTGCAAAATCAAATG ATGCTGTTTCAGAACCAGCCTGATCATAGACGATTGCGGACGCTTGCCAGCGGAGCGTTT ACGCCGAGAACGACAGAGAGTTATCAGCCGTATATCATTGAAACTGTCCATCATTTGCTT GATCAAGTGCAAGGTAAAAAAAAGATGGAGGTCATTTCGGACTTTGCTTTTCCTTTAGCA AGTTTTGTCATAGCTAACATTATAGGTGTACCGGAGGAAGATAGGGAGCAATTAAAGGAG TGGGCTGCGAGTCTCATTCAAACGATTGATTTTACCCGCTCAAGAAAGGCATTAACAGAG GGCAATATTATGGCTGTGCAGGCTATGGCATATTTCAAAGAGCTGATTCAAAAGAGAAAA CGCCACCCTCAACAGGATATGATCAGCATGCTCTTGAAGGGGAGAGAAAAGGATAAGCTG ACGGAAGAGGAGGCGGCATCTACGTGCATATTGCTGGCGATCGCCGGACATGAGACAACG GTCAATCTCATCAGCAATTCAGTCCTTTGTCTGCTGCAGCATCCAGAACAGCTTTTGAAA CTGAGAGAAAATCCAGATCTTATTGGTACCGCAGTCGAGGAATGTTTACGCTATGAAAGC CCCACGCAAATGACAGCCAGAGTTGCGTCAGAGGATATTGACATCTGCGGGGTGACGATC CGTCAAGGAGAACAAGTCTATCTTTTGTTAGGAGCGGCTAATCGAGACCCTAGCATATTC ACGAACCCCGATGTCTTCGATATTACGAGAAGTCCTAATCCGCATCTTTCATTCGGGCAT GGCCATCATGTTTGCTTAGGGTCCTCGCTGGCACGATTAGAAGCGCAAATTGCGATTAAC ACTCTTCTGCAGCGAATGCCCAGCCTTAATCTTGCGGATTTTGAATGGCGGTATCGGCCG CTTTTTGGATTTCGGGCGCTTGAGGAGCTGCCGGTGACTTTTGAATAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P53554 UniProtKB Entry Name BIOI_BACSU GenBank Protein ID 1277025 GenBank Gene ID U51868 PDB ID(s) 3EJB, 3EJD, 3EJE KEGG ID bsu:BSU30190 NCBI Gene ID 935928 - General References
- Bower S, Perkins JB, Yocum RR, Howitt CL, Rahaim P, Pero J: Cloning, sequencing, and characterization of the Bacillus subtilis biotin biosynthetic operon. J Bacteriol. 1996 Jul;178(14):4122-30. [Article]
- Lapidus A, Galleron N, Sorokin A, Ehrlich SD: Sequencing and functional annotation of the Bacillus subtilis genes in the 200 kb rrnB-dnaB region. Microbiology. 1997 Nov;143 ( Pt 11):3431-41. [Article]
- Kunst F, Ogasawara N, Moszer I, Albertini AM, Alloni G, Azevedo V, Bertero MG, Bessieres P, Bolotin A, Borchert S, Borriss R, Boursier L, Brans A, Braun M, Brignell SC, Bron S, Brouillet S, Bruschi CV, Caldwell B, Capuano V, Carter NM, Choi SK, Cordani JJ, Connerton IF, Cummings NJ, Daniel RA, Denziot F, Devine KM, Dusterhoft A, Ehrlich SD, Emmerson PT, Entian KD, Errington J, Fabret C, Ferrari E, Foulger D, Fritz C, Fujita M, Fujita Y, Fuma S, Galizzi A, Galleron N, Ghim SY, Glaser P, Goffeau A, Golightly EJ, Grandi G, Guiseppi G, Guy BJ, Haga K, Haiech J, Harwood CR, Henaut A, Hilbert H, Holsappel S, Hosono S, Hullo MF, Itaya M, Jones L, Joris B, Karamata D, Kasahara Y, Klaerr-Blanchard M, Klein C, Kobayashi Y, Koetter P, Koningstein G, Krogh S, Kumano M, Kurita K, Lapidus A, Lardinois S, Lauber J, Lazarevic V, Lee SM, Levine A, Liu H, Masuda S, Mauel C, Medigue C, Medina N, Mellado RP, Mizuno M, Moestl D, Nakai S, Noback M, Noone D, O'Reilly M, Ogawa K, Ogiwara A, Oudega B, Park SH, Parro V, Pohl TM, Portelle D, Porwollik S, Prescott AM, Presecan E, Pujic P, Purnelle B, Rapoport G, Rey M, Reynolds S, Rieger M, Rivolta C, Rocha E, Roche B, Rose M, Sadaie Y, Sato T, Scanlan E, Schleich S, Schroeter R, Scoffone F, Sekiguchi J, Sekowska A, Seror SJ, Serror P, Shin BS, Soldo B, Sorokin A, Tacconi E, Takagi T, Takahashi H, Takemaru K, Takeuchi M, Tamakoshi A, Tanaka T, Terpstra P, Togoni A, Tosato V, Uchiyama S, Vandebol M, Vannier F, Vassarotti A, Viari A, Wambutt R, Wedler H, Weitzenegger T, Winters P, Wipat A, Yamamoto H, Yamane K, Yasumoto K, Yata K, Yoshida K, Yoshikawa HF, Zumstein E, Yoshikawa H, Danchin A: The complete genome sequence of the gram-positive bacterium Bacillus subtilis. Nature. 1997 Nov 20;390(6657):249-56. [Article]
- Stok JE, De Voss J: Expression, purification, and characterization of BioI: a carbon-carbon bond cleaving cytochrome P450 involved in biotin biosynthesis in Bacillus subtilis. Arch Biochem Biophys. 2000 Dec 15;384(2):351-60. [Article]
- Green AJ, Rivers SL, Cheeseman M, Reid GA, Quaroni LG, Macdonald ID, Chapman SK, Munro AW: Expression, purification and characterization of cytochrome P450 Biol: a novel P450 involved in biotin synthesis in Bacillus subtilis. J Biol Inorg Chem. 2001 Jun;6(5-6):523-33. [Article]
- Lawson RJ, Leys D, Sutcliffe MJ, Kemp CA, Cheesman MR, Smith SJ, Clarkson J, Smith WE, Haq I, Perkins JB, Munro AW: Thermodynamic and biophysical characterization of cytochrome P450 BioI from Bacillus subtilis. Biochemistry. 2004 Oct 5;43(39):12410-26. [Article]
- Cryle MJ, De Voss JJ: Carbon-carbon bond cleavage by cytochrome p450(BioI)(CYP107H1). Chem Commun (Camb). 2004 Jan 7;(1):86-7. Epub 2003 Nov 17. [Article]
- Cryle MJ, Schlichting I: Structural insights from a P450 Carrier Protein complex reveal how specificity is achieved in the P450(BioI) ACP complex. Proc Natl Acad Sci U S A. 2008 Oct 14;105(41):15696-701. doi: 10.1073/pnas.0805983105. Epub 2008 Oct 6. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Heptyl 1-Thiohexopyranoside experimental unknown target Details