Dihydrofolate reductase

BE0004138ProteinStaphylococcus aureusfolA

Key enzyme in folate metabolism. It is acted on by 4 drugs in DrugBank.

Gene name
folA
UniProtKB entry
P0A017Swiss-Prot
Residues / weight
159 residues · 18,251 Da
Also known as
1.5.1.3 · DHFR

Resolves to

Protein
UniProtP0A017UniProt nameDYR_STAAU
Gene
NCBI Gene23197237GenBank49313
Structure
PDB2W9GPDB2W9HPDB3FRA
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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8+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Dihydrofolate reductase, and which indications are they being tested in?

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