Biotin carboxylase

BE0004154ProteinEscherichia coli (strain K12)accC

This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. It is acted on by 11 drugs in DrugBank.

Gene name
accC
UniProtKB entry
P24182Swiss-Prot
Residues / weight
449 residues · 49,320 Da
Also known as
6.3.4.14 · ACC · Acetyl-CoA carboxylase subunit A · Acetyl-coenzyme A carboxylase biotin carboxylase subunit A · fabG

Resolves to

Protein
UniProtP24182UniProt nameACCC_ECOLI
Gene
NCBI Gene947761GenBank145896
Pharmacology
KEGGecj:JW3224
Structure
PDB1BNCPDB1DV1PDB1DV2
Drugs

What you can answer from here — as of September 07, 2019

11DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
9GO termsFunction, process and component, as structured annotations
Sign in
3Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
20+ReferencesStructured and connected to the statements they support
Sign in

Which compounds in development act on Biotin carboxylase, and which indications are they being tested in?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In