Myocardin-related transcription factor A

BE0004156ProteinHumansMRTFA

Transcription coactivator that associates with the serum response factor (SRF) transcription factor to control expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration (PubMed:26224645). It is acted on by 1 drug in DrugBank.

Gene name
MRTFA
UniProtKB entry
Q969V6Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
931 residues · 98,918 Da
Also known as
KIAA1438 · MAL · Megakaryoblastic leukemia 1 protein · Megakaryocytic acute leukemia protein · MKL/myocardin-like protein 1

Resolves to

Protein
UniProtQ969V6UniProt nameMRTFA_HUMAN
Gene
HGNCHGNC:14334NCBI Gene57591GenBank14041618GeneCardsMRTFA
Pharmacology
KEGGhsa:57591
Structure
PDB2KVUPDB2KW9
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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17+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Myocardin-related transcription factor A, and which indications are they being tested in?

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