N-acetylneuraminic acid outer membrane channel protein NanC

BE0004175ProteinEscherichia coli (strain K12)nanC

Outer membrane channel protein allowing the entry of N-acetylneuraminic acid (Neu5Ac, the most abundant sialic acid on host cell surfaces) into the bacteria (PubMed:15743943, PubMed:22246445). It is acted on by 1 drug in DrugBank.

Gene name
nanC
UniProtKB entry
P69856Swiss-Prot
Cellular location
Cell outer membrane
Residues / weight
238 residues · 27,888 Da
Also known as
N-acetylneuraminic acid-inducible outer membrane channel · NanR-regulated channel · Porin NanC · Probable N-acetylneuraminic acid outer membrane channel protein NanC · yjhA

Resolves to

Protein
UniProtP69856UniProt nameNANC_ECOLI
Gene
NCBI Gene946843GenBank1263173
Pharmacology
KEGGecj:JW5778
Structure
PDB2WJQPDB2WJR
Drugs

What you can answer from here — as of May 03, 2025

1DrugApproved to experimental, with action, bond type and pharmacological action
Sign in
9GO termsFunction, process and component, as structured annotations
Sign in
1Pfam domainDomain architecture mapped to Pfam families and clans
Sign in
6+ReferencesStructured and connected to the statements they support
Sign in

Which compounds in development act on N-acetylneuraminic acid outer membrane channel protein NanC, and which indications are they being tested in?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In