Beta-lactamase
Details
- Name
- Beta-lactamase
- Kind
- protein
- Synonyms
- 3.5.2.6
- Gene Name
- cphA
- UniProtKB Entry
- P26918Swiss-Prot
- Organism
- Aeromonas hydrophila
- NCBI Taxonomy ID
- 644
- Amino acid sequence
>lcl|BSEQ0019534|Beta-lactamase MMKGWMKCGLAGAVVLMASFWGGSVRAAGMSLTQVSGPVYVVEDNYYVQENSMVYFGAKG VTVVGATWTPDTARELHKLIKRVSRKPVLEVINTNYHTDRAGGNAYWKSIGAKVVSTRQT RDLMKSDWAEIVAFTRKGLPEYPDLPLVLPNVVHDGDFTLQEGKVRAFYAGPAHTPDGIF VYFPDEQVLYGNCILKEKLGNLSFADVKAYPQTLERLKAMKLPIKTVIGGHDSPLHGPEL IDHYEALIKAAPQS
- Number of residues
- 254
- Molecular Weight
- 28016.185
- Theoretical pI
- 8.9
- GO Classification
- Functionsbeta-lactamase activity / zinc ion bindingProcessesantibiotic catabolic process / response to antibioticComponentsperiplasmic space
- General Function
- Confers resistance to the different beta-lactams antibiotics (penicillin, cephalosporin and carbapenem) via the hydrolysis of the beta-lactam ring (PubMed:15588826, PubMed:17307979, PubMed:1856163, PubMed:19651913, PubMed:2327760). It is able to hydrolyze penicillin and imipenem, but is much less active against cephalothin, cefotaxime, meropenem and ceftazidime (PubMed:1856163, PubMed:2327760).
- Specific Function
- beta-lactamase activity
- Pfam Domain Function
- Lactamase_B (PF00753)
- Signal Regions
- 1-27
- Transmembrane Regions
- Not Available
- Cellular Location
- Periplasm
- Gene sequence
>lcl|BSEQ0007978|765 bp ATGATGAAAGGTTGGATGAAGTGTGGATTGGCCGGCGCCGTGGTGCTGATGGCGAGTTTC TGGGGTGGCAGCGTGCGGGCGGCGGGGATGTCGCTGACGCAGGTGAGCGGCCCTGTGTAT GTGGTAGAGGACAACTACTACGTGCAGGAAAATTCCATGGTCTATTTCGGGGCCAAGGGC GTGACTGTGGTGGGGGCGACCTGGACGCCGGACACCGCCCGCGAGCTGCACAAGCTGATC AAACGGGTCAGCCGCAAGCCGGTGCTGGAGGTGATCAACACCAACTACCACACCGACCGG GCTGGCGGTAACGCCTACTGGAAGTCCATCGGTGCCAAGGTGGTGTCGACCCGCCAGACC CGGGATCTGATGAAGAGCGACTGGGCCGAGATTGTTGCCTTTACCCGCAAGGGGCTGCCG GAGTACCCGGATCTGCCGCTGGTGCTGCCCAACGTGGTGCACGATGGCGACTTCACGCTG CAAGAGGGCAAGGTGCGCGCCTTCTACGCGGGCCCGGCCCATACGCCGGACGGCATCTTT GTCTACTTCCCCGACGAGCAGGTGCTCTATGGCAACTGCATTCTCAAGGAGAAGCTGGGC AACCTGAGCTTTGCCGATGTGAAGGCCTATCCACAGACGCTTGAGCGGCTGAAAGCGATG AAGCTGCCGATCAAGACGGTGATCGGCGGTCACGACTCACCGCTGCACGGCCCCGAGCTG ATTGATCACTACGAAGCGCTGATCAAGGCCGCACCCCAGTCATAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P26918 UniProtKB Entry Name BLAB_AERHY GenBank Protein ID 38824 GenBank Gene ID X57102 PDB ID(s) 1X8G, 1X8H, 1X8I, 2GKL, 2QDS, 3F9O, 3FAI, 3IOF, 3IOG, 3SW3, 3T9M - General References
- Massidda O, Rossolini GM, Satta G: The Aeromonas hydrophila cphA gene: molecular heterogeneity among class B metallo-beta-lactamases. J Bacteriol. 1991 Aug;173(15):4611-7. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Epicaptopril experimental unknown target Details