Metallo-beta-lactamase type 2

BE0004195ProteinAeromonas hydrophilacphA

Confers resistance to the different beta-lactams antibiotics (penicillin, cephalosporin and carbapenem) via the hydrolysis of the beta-lactam ring (PubMed:15588826, PubMed:17307979, PubMed:1856163, PubMed:19651913, PubMed:2327760). It is acted on by 1 drug in DrugBank.

Gene name
cphA
UniProtKB entry
P26918Swiss-Prot
Cellular location
Periplasm
Residues / weight
254 residues · 28,016 Da
Also known as
3.5.2.6 · B2 metallo-beta-lactamase · Beta-lactamase · Beta-lactamase II · Carbapenem-hydrolyzing metallo-beta-lactamase

Resolves to

Protein
UniProtP26918UniProt nameBLAB_AERHY
Gene
GenBank38824
Structure
PDB1X8GPDB1X8HPDB1X8I
Drugs

What you can answer from here — as of May 03, 2025

1DrugApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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2+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Metallo-beta-lactamase type 2, and which indications are they being tested in?

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