Guanylyl cyclase-activating protein 1

BE0004244ProteinHumansGUCA1A

Stimulates retinal guanylyl cyclase when free calcium ions concentration is low and inhibits guanylyl cyclase when free calcium ions concentration is elevated (PubMed:18706439, PubMed:19459154, PubMed:30184081, PubMed:30622141). It is acted on by 1 drug in DrugBank.

Gene name
GUCA1A
UniProtKB entry
P43080Swiss-Prot
Cellular location
Membrane
Residues / weight
201 residues · 22,920 Da
Also known as
C6orf131 · GCAP · GCAP 1 · GCAP1 · Guanylate cyclase activator 1A

Resolves to

Protein
UniProtP43080UniProt nameGUC1A_HUMAN
Gene
HGNCHGNC:4678NCBI Gene2978GenBank623403GeneCardsGUCA1A
Pharmacology
KEGGhsa:2978
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
Sign in
5GO termsFunction, process and component, as structured annotations
Sign in
2Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
13+ReferencesStructured and connected to the statements they support
Sign in

Which compounds in development act on Guanylyl cyclase-activating protein 1, and which indications are they being tested in?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In