Actin-related protein 2/3 complex subunit 1B

BE0004249ProteinHumansARPC1B

Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:11741539, PubMed:9230079). It is acted on by 2 drugs in DrugBank.

Gene name
ARPC1B
UniProtKB entry
O15143Swiss-Prot
Cellular location
Cytoplasm, cytoskeleton
Residues / weight
372 residues · 40,949 Da
Also known as
ARC41 · Arp2/3 complex 41 kDa subunit · p41-ARC

Resolves to

Protein
UniProtO15143UniProt nameARC1B_HUMAN
Gene
HGNCHGNC:704NCBI Gene10095GenBank2282034GeneCardsARPC1B
Pharmacology
KEGGhsa:10095
Structure
PDB6UHCPDB6YW6PDB8P94
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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15+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Actin-related protein 2/3 complex subunit 1B, and which indications are they being tested in?

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