Actin-related protein 2

BE0004250ProteinHumansACTR2

ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9000076). It is acted on by 2 drugs in DrugBank.

Gene name: ACTR2
UniProtKB entry: P61160Swiss-Prot
Cellular location: Cytoplasm, cytoskeleton
Residues / weight: 394 residues · 44,760 Da
Also known as: Actin-like protein 2 · ARP2

Resolves to

Protein

UniProtP61160UniProt nameARP2_HUMAN

Gene

HGNCHGNC:169NCBI Gene10097GenBank2282030GeneCardsACTR2

Pharmacology

KEGGhsa:10097

Structure

PDB6UHCPDB6YW6PDB6YW7

Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action

10GO termsFunction, process and component, as structured annotations

1Pfam domainDomain architecture mapped to Pfam families and clans

13+ReferencesStructured and connected to the statements they support

Which compounds in development act on Actin-related protein 2, and which indications are they being tested in?

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