3-ketoacyl-CoA thiolase

BE0004257ProteinPseudomonas fragifadA

Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed. It is acted on by 1 drug in DrugBank.

Gene name
fadA
UniProtKB entry
P28790Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
391 residues · 41,606 Da
Also known as
2.3.1.16 · Acetyl-CoA acyltransferase · Beta-ketothiolase · faoB · Fatty acid oxidation complex subunit beta

Resolves to

Protein
UniProtP28790UniProt nameFADA_PSEFR
Gene
GenBank391839
Structure
PDB1WDKPDB1WDLPDB1WDM
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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2+ReferencesStructured and connected to the statements they support
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Which compounds in development act on 3-ketoacyl-CoA thiolase, and which indications are they being tested in?

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