O-GlcNAcase BT_4395

BE0004258ProteinBacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)

Can hydrolyze the glycosidic link of O-GlcNAcylated proteins. It is acted on by 3 drugs in DrugBank.

UniProtKB entry
Q89ZI2Swiss-Prot
Residues / weight
737 residues · 84,485 Da
Also known as
3.2.1.169 · Beta-hexosaminidase · Beta-N-acetylglucosaminidase · Beta-N-acetylhexosaminidase · Hexosaminidase B

Resolves to

Protein
UniProtQ89ZI2UniProt nameOGA_BACTN
Gene
NCBI Gene1074035GenBank29337303
Pharmacology
KEGGbth:BT_4395
Structure
PDB2CHNPDB2CHOPDB2J47
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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5+ReferencesStructured and connected to the statements they support
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Which approved drugs act on O-GlcNAcase BT_4395, how selective are they, and which programs against it are still in active trials?

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