Naphthalene 1,2-dioxygenase subunit alpha
Details
- Name
- Naphthalene 1,2-dioxygenase subunit alpha
- Kind
- protein
- Synonyms
- 1.14.12.12
- nahA3
- nahAC
- Naphthalene 1,2-dioxygenase ISP alpha
- ndoC2
- Gene Name
- ndoB
- UniProtKB Entry
- P0A110Swiss-Prot
- Organism
- Pseudomonas putida
- NCBI Taxonomy ID
- 303
- Amino acid sequence
>lcl|BSEQ0017386|Naphthalene 1,2-dioxygenase subunit alpha MNYNNKILVSESGLSQKHLIHGDEELFQHELKTIFARNWLFLTHDSLIPAPGDYVTAKMG IDEVIVSRQNDGSIRAFLNVCRHRGKTLVSVEAGNAKGFVCSYHGWGFGSNGELQSVPFE KDLYGESLNKKCLGLKEVARVESFHGFIYGCFDQEAPPLMDYLGDAAWYLEPMFKHSGGL ELVGPPGKVVIKANWKAPAENFVGDAYHVGWTHASSLRSGESIFSSLAGNAALPPEGAGL QMTSKYGSGMGVLWDGYSGVHSADLVPELMAFGGAKQERLNKEIGDVRARIYRSHLNCTV FPNNSMLTCSGVFKVWNPIDANTTEVWTYAIVEKDMPEDLKRRLADSVQRTFGPAGFWES DDNDNMETASQNGKKYQSRDSDLLSNLGFGEDVYGDAVYPGVVGKSAIGETSYRGFYRAY QAHVSSSNWAEFEHASSTWHTELTKTTDR
- Number of residues
- 449
- Molecular Weight
- 49607.19
- Theoretical pI
- 5.86
- GO Classification
- Functions2 iron, 2 sulfur cluster binding / iron ion binding / naphthalene 1,2-dioxygenase activityProcessesaromatic compound catabolic process
- General Function
- Component of the naphthalene dioxygenase (NDO) multicomponent enzyme system which catalyzes the incorporation of both atoms of molecular oxygen into naphthalene to form cis-(1R,2S)-dihydroxy-1,2-dihydronaphthalene. The alpha subunit has a catalytic role in the holoenzyme. Also able to catalyze the cis-dihydroxylation of biphenyl and phenanthrene (PubMed:10692370).
- Specific Function
- 2 iron, 2 sulfur cluster binding
- Pfam Domain Function
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0017387|PG:1343187 NAHAC, PDTG1P19; PSEUDOMONAS PUTIDA NCIB 9816-4 PLASMID PDTG1; NAPHTHALENE 1,2-DIOXYGENASE IRON SULFUR PROTEIN COMPONENT LARGE SUBUNIT; K14579 NAPHTHALENE 1,2-DIOXYGENASE SUBUNIT ALPHA [EC:1.14.12.12] (N) ATGAATTACAATAATAAAATCTTGGTAAGTGAATCTGGTCTGAGCCAAAAGCACCTGATT CATGGCGATGAAGAACTTTTCCAACATGAACTGAAAACCATTTTTGCGCGGAACTGGCTT TTTCTCACTCATGATAGCCTGATTCCTGCCCCCGGCGACTATGTTACCGCAAAAATGGGG ATTGACGAGGTCATCGTCTCCCGGCAGAACGACGGTTCGATTCGTGCTTTTCTGAACGTT TGCCGGCATCGTGGCAAGACGCTGGTGAGCGTGGAAGCCGGCAATGCCAAAGGTTTTGTT TGCAGCTATCACGGCTGGGGCTTCGGCTCCAACGGTGAACTGCAGAGCGTTCCATTTGAA AAAGATCTGTACGGCGAGTCGCTCAATAAAAAATGTCTGGGGTTGAAAGAAGTCGCTCGC GTGGAGAGCTTCCATGGCTTCATCTACGGTTGCTTCGACCAGGAGGCCCCTCCTCTTATG GACTATCTGGGTGACGCTGCTTGGTACCTGGAACCTATGTTCAAGCATTCCGGCGGTTTA GAACTGGTCGGTCCTCCAGGCAAGGTTGTGATCAAGGCCAACTGGAAGGCACCCGCGGAA AACTTTGTGGGAGATGCATACCACGTGGGTTGGACGCACGCGTCTTCGCTTCGCTCGGGG GAGTCTATCTTCTCGTCGCTCGCTGGCAATGCGGCGCTACCACCTGAAGGCGCAGGCTTG CAAATGACCTCCAAATACGGCAGCGGCATGGGTGTGTTGTGGGACGGATATTCAGGTGTG CATAGCGCAGACTTGGTTCCGGAATTGATGGCATTCGGAGGCGCAAAGCAGGAAAGGCTG AACAAAGAAATTGGCGATGTTCGCGCTCGGATTTATCGCAGCCACCTCAACTGCACCGTT TTCCCGAACAACAGCATGCTGACCTGCTCGGGTGTTTTCAAAGTATGGAACCCGATCGAC GCAAACACCACCGAGGTCTGGACCTACGCCATTGTCGAAAAAGACATGCCTGAGGATCTC AAGCGCCGCTTGGCCGACTCTGTTCAGCGAACGTTCGGGCCTGCTGGCTTCTGGGAAAGC GACGACAATGACAATATGGAAACAGCTTCGCAAAACGGCAAGAAATATCAATCAAGAGAT AGTGATCTGCTTTCAAACCTTGGTTTCGGTGAGGACGTATACGGCGACGCGGTCTATCCA GGCGTCGTCGGCAAATCGGCGATCGGCGAGACCAGTTATCGTGGTTTCTACCGGGCTTAC CAGGCACACGTCAGCAGCTCCAACTGGGCTGAGTTCGAGCATGCCTCTAGTACTTGGCAT ACTGAACTTACGAAGACTACTGATCGCTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P0A110 UniProtKB Entry Name NDOB_PSEPU GenBank Protein ID 151393 GenBank Gene ID M23914 PDB ID(s) 1EG9, 1NDO, 1O7G, 1O7H, 1O7M, 1O7N, 1O7P, 1O7W, 1UUV, 1UUW NCBI Gene ID 1343187 - General References
- Kurkela S, Lehvaslaiho H, Palva ET, Teeri TH: Cloning, nucleotide sequence and characterization of genes encoding naphthalene dioxygenase of Pseudomonas putida strain NCIB9816. Gene. 1988 Dec 20;73(2):355-62. [Article]
- Parales JV, Kumar A, Parales RE, Gibson DT: Cloning and sequencing of the genes encoding 2-nitrotoluene dioxygenase from Pseudomonas sp. JS42. Gene. 1996 Nov 28;181(1-2):57-61. [Article]
- Simon MJ, Osslund TD, Saunders R, Ensley BD, Suggs S, Harcourt A, Suen WC, Cruden DL, Gibson DT, Zylstra GJ: Sequences of genes encoding naphthalene dioxygenase in Pseudomonas putida strains G7 and NCIB 9816-4. Gene. 1993 May 15;127(1):31-7. [Article]
- Kauppi B, Lee K, Carredano E, Parales RE, Gibson DT, Eklund H, Ramaswamy S: Structure of an aromatic-ring-hydroxylating dioxygenase-naphthalene 1,2-dioxygenase. Structure. 1998 May 15;6(5):571-86. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details (1R, 2S)-cis 1,2 dihydroxy-1,2-dihydronaphthalene experimental unknown target Details