Naphthalene 1,2-dioxygenase system, large oxygenase component

BE0004259ProteinPseudomonas putidandoB

Component of the naphthalene dioxygenase (NDO) multicomponent enzyme system which catalyzes the incorporation of both atoms of molecular oxygen into naphthalene to form cis-(1R,2S)-dihydroxy-1,2-dihydronaphthalene. It is acted on by 1 drug in DrugBank.

Gene name
ndoB
UniProtKB entry
P0A110Swiss-Prot
Residues / weight
449 residues · 49,607 Da
Also known as
1.14.12.12 · ISP NAP · nahA3 · nahAC · Naphthalene 1,2-dioxygenase ISP alpha

Resolves to

Protein
UniProtP0A110UniProt nameNDOB_PSEPU
Gene
NCBI Gene1343187GenBank151393
Structure
PDB1EG9PDB1NDOPDB1O7G
Drugs

What you can answer from here — as of May 03, 2025

1DrugApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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5+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Naphthalene 1,2-dioxygenase system, large oxygenase component, and which indications are they being tested in?

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