Naphthalene 1,2-dioxygenase subunit beta

Details

Name
Naphthalene 1,2-dioxygenase subunit beta
Kind
protein
Synonyms
  • 1.14.12.12
  • nahAD
  • Naphthalene 1,2-dioxygenase ISP beta
Gene Name
ndoC
UniProtKB Entry
P0A112Swiss-Prot
Organism
Pseudomonas putida
NCBI Taxonomy ID
303
Amino acid sequence
>lcl|BSEQ0012969|Naphthalene 1,2-dioxygenase subunit beta
MMINIQEDKLVSAHDAEEILRFFNCHDSALQQEATTLLTQEAHLLDIQAYRAWLEHCVGS
EVQYQVISRELRAASERRYKLNEAMNVYNENFQQLKVRVEHQLDPQNWGNSPKLRFTRFI
TNVQAAMDVNDKELLHIRSNVILHRARRGNQVDVFYAAREDKWKRGEGGVRKLVQRFVDY
PERILQTHNLMVFL
Number of residues
194
Molecular Weight
22934.935
Theoretical pI
7.73
GO Classification
Functions
naphthalene 1,2-dioxygenase activity
Processes
aromatic compound catabolic process
General Function
Component of the naphthalene dioxygenase (NDO) multicomponent enzyme system which catalyzes the incorporation of both atoms of molecular oxygen into naphthalene to form cis-(1R,2S)-dihydroxy-1,2-dihydronaphthalene. The beta subunit seems to have a structural role in the holoenzyme. Also able to catalyze the cis-dihydroxylation of biphenyl and phenanthrene (PubMed:10692370).
Specific Function
dioxygenase activity
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0012970|Naphthalene 1,2-dioxygenase subunit beta (ndoC)
ATGATGATCAATATTCAAGAAGACAAGCTGGTTTCCGCCCACGACGCCGAAGAGATTCTT
CGTTTCTTCAATTGCCACGACTCTGCTTTGCAACAAGAAGCCACTACGCTGCTGACCCAG
GAAGCGCATTTGTTGGACATTCAGGCTTACCGTGCTTGGTTAGAGCACTGCGTGGGGTCA
GAGGTGCAATATCAGGTCATTTCACGCGAACTGCGCGCAGCTTCAGAGCGTCGTTATAAG
CTCAATGAAGCCATGAACGTTTACAACGAAAATTTTCAGCAACTGAAAGTTCGAGTTGAG
CATCAACTGGATCCGCAAAACTGGGGCAACAGCCCGAAGCTGCGCTTTACTCGCTTTATC
ACCAACGTCCAGGCCGCAATGGACGTAAATGACAAAGAGCTACTTCACATCCGCTCCAAC
GTCATTCTGCACCGGGCACGACGTGGCAATCAGGTCGATGTCTTCTACGCCGCCCGGGAA
GATAAATGGAAACGTGGCGAAGGTGGAGTACGAAAATTGGTCCAGCGATTCGTCGATTAC
CCAGAGCGCATACTTCAGACGCACAATCTGATGGTCTTTCTGTGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP0A112
UniProtKB Entry NameNDOC_PSEPU
GenBank Protein ID151393
GenBank Gene IDM23914
PDB ID(s)1EG9, 1NDO, 1O7G, 1O7H, 1O7M, 1O7N, 1O7P, 1O7W, 1UUV, 1UUW
KEGG IDpg:1343188
NCBI Gene ID1343188
General References
  1. Kurkela S, Lehvaslaiho H, Palva ET, Teeri TH: Cloning, nucleotide sequence and characterization of genes encoding naphthalene dioxygenase of Pseudomonas putida strain NCIB9816. Gene. 1988 Dec 20;73(2):355-62. [Article]
  2. Parales JV, Kumar A, Parales RE, Gibson DT: Cloning and sequencing of the genes encoding 2-nitrotoluene dioxygenase from Pseudomonas sp. JS42. Gene. 1996 Nov 28;181(1-2):57-61. [Article]
  3. Simon MJ, Osslund TD, Saunders R, Ensley BD, Suggs S, Harcourt A, Suen WC, Cruden DL, Gibson DT, Zylstra GJ: Sequences of genes encoding naphthalene dioxygenase in Pseudomonas putida strains G7 and NCIB 9816-4. Gene. 1993 May 15;127(1):31-7. [Article]
  4. Kauppi B, Lee K, Carredano E, Parales RE, Gibson DT, Eklund H, Ramaswamy S: Structure of an aromatic-ring-hydroxylating dioxygenase-naphthalene 1,2-dioxygenase. Structure. 1998 May 15;6(5):571-86. [Article]

Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
(1R, 2S)-cis 1,2 dihydroxy-1,2-dihydronaphthaleneexperimentalunknowntargetDetails