DNA-directed RNA polymerase subunit alpha

Details

Name
DNA-directed RNA polymerase subunit alpha
Kind
protein
Synonyms
  • 2.7.7.6
  • RNA polymerase subunit alpha
  • RNAP subunit alpha
  • Transcriptase subunit alpha
Gene Name
rpoA
UniProtKB Entry
Q5SHR6Swiss-Prot
Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
NCBI Taxonomy ID
300852
Amino acid sequence
>lcl|BSEQ0019548|DNA-directed RNA polymerase subunit alpha
MLDSKLKAPVFTVRTQGREYGEFVLEPLERGFGVTLGNPLRRILLSSIPGTAVTSVYIED
VLHEFSTIPGVKEDVVEIILNLKELVVRFLNPSLQTVTLLLKAEGPKEVKARDFLPVADV
EIMNPDLHIATLEEGGRLNMEVRVDRGVGYVPAEKHGIKDRINAIPVDAVFSPVRRVAFQ
VEDTRLGQRTDLDKLTLRIWTDGSVTPLEALNQAVEILREHLTYFSNPQAAAVAAPEEAK
EPEAPPEQEEELDLPLEELGLSTRVLHSLKEEGIESVRALLALNLKDLKNIPGIGERSLE
EIKEALEKKGFTLKE
Number of residues
315
Molecular Weight
35012.91
Theoretical pI
4.64
GO Classification
Functions
DNA binding / DNA-directed RNA polymerase activity
Processes
DNA repair / transcription, DNA-templated
General Function
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Specific Function
DNA binding
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
Not Available
Cellular Location
Cytoplasmic
Gene sequence
>lcl|BSEQ0019549|DNA-directed RNA polymerase subunit alpha (rpoA)
ATGTTGGATTCCAAGCTCAAGGCCCCGGTCTTCACGGTGCGCACCCAGGGGCGGGAGTAC
GGGGAGTTCGTCCTGGAGCCCCTGGAGCGGGGCTTCGGCGTCACCCTGGGAAACCCCCTG
CGGCGCATCCTCCTTTCCTCCATCCCTGGGACCGCGGTCACCAGCGTCTACATTGAGGAC
GTCCTCCACGAGTTCTCCACCATCCCCGGGGTCAAGGAGGACGTGGTGGAGATCATCCTC
AACCTCAAGGAGCTGGTGGTCCGGTTCCTGAACCCCAGCCTCCAGACCGTGACCCTCCTC
CTCAAGGCCGAGGGCCCCAAGGAGGTGAAGGCGCGGGACTTCCTTCCCGTGGCCGACGTG
GAGATCATGAACCCCGACCTCCACATCGCCACCCTGGAGGAGGGGGGTCGGCTCAACATG
GAGGTCCGGGTGGACCGGGGGGTGGGGTACGTCCCGGCGGAGAAGCACGGCATCAAGGAC
CGGATCAACGCCATCCCGGTGGACGCCGTCTTCTCCCCGGTGCGCCGCGTGGCCTTCCAG
GTGGAGGACACCCGCCTGGGGCAGCGCACCGACCTGGACAAGCTCACCCTCAGGATCTGG
ACCGACGGCTCCGTCACCCCCCTCGAGGCCCTGAACCAGGCGGTGGAGATCCTCCGGGAG
CACCTCACCTACTTCTCCAACCCCCAGGCGGCCGCCGTGGCGGCCCCCGAGGAGGCCAAG
GAGCCCGAGGCGCCGCCAGAGCAGGAGGAGGAGCTGGACCTGCCCTTGGAGGAGCTCGGC
CTCTCCACCCGGGTGCTCCACAGCCTCAAGGAGGAGGGCATTGAGTCCGTCCGGGCCCTT
CTCGCCCTCAACCTCAAGGACCTGAAGAACATCCCCGGGATTGGGGAGCGGAGCCTGGAG
GAGATCAAGGAAGCCCTGGAGAAGAAGGGCTTCACCCTGAAGGAGTGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDQ5SHR6
UniProtKB Entry NameRPOA_THET8
GenBank Protein ID4519419
GenBank Gene IDAB024328
PDB ID(s)1ZYR, 2A68, 2A69, 2A6E, 2A6H, 2BE5, 2CW0, 2O5I, 2O5J, 3AOH, 3AOI, 3DXJ, 3WOD, 4G7H, 4G7O, 4G7Z, 4GZY, 4GZZ, 4MQ9, 4OIN, 4OIO, 4OIP, 4OIQ, 4OIR, 4WQS, 4WQT
KEGG IDttj:TTHA1664
NCBI Gene ID3169128
General References
  1. Wada T, Yamazaki T, Kuramitsu S, Kyogoku Y: Cloning of the RNA polymerase alpha subunit gene from Thermus thermophilus HB8 and characterization of the protein. J Biochem. 1999 Jan;125(1):143-50. [Article]

Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
Methyl [(1E,5R)-5-{3-[(2E,4E)-2,5-dimethyl-2,4-octadienoyl]-2,4-dioxo-3,4-dihydro-2H-pyran-6-yl}hexylidene]carbamateexperimentalunknowntargetDetails