4-hydroxyphenylpyruvate dioxygenase
Details
- Name
- 4-hydroxyphenylpyruvate dioxygenase
- Kind
- protein
- Synonyms
- 1.13.11.27
- 4HPPD
- Gene Name
- hpd
- UniProtKB Entry
- Q53586Swiss-Prot
- Organism
- Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680)
- NCBI Taxonomy ID
- 227882
- Amino acid sequence
>lcl|BSEQ0012974|4-hydroxyphenylpyruvate dioxygenase MTQTTHHTPDTARQADPFPVKGMDAVVFAVGNAKQAAHYYSTAFGMQLVAYSGPENGSRE TASYVLTNGSARFVLTSVIKPATPWGHFLADHVAEHGDGVVDLAIEVPDARAAHAYAIEH GARSVAEPYELKDEHGTVVLAAIATYGKTRHTLVDRTGYDGPYLPGYVAAAPIVEPPAHR TFQAIDHCVGNVELGRMNEWVGFYNKVMGFTNMKEFVGDDIATEYSALMSKVVADGTLKV KFPINEPALAKKKSQIDEYLEFYGGAGVQHIALNTGDIVETVRTMRAAGVQFLDTPDSYY DTLGEWVGDTRVPVDTLRELKILADRDEDGYLLQIFTKPVQDRPTVFFEIIERHGSMGFG KGNFKALFEAIEREQEKRGNL
- Number of residues
- 381
- Molecular Weight
- 41862.91
- Theoretical pI
- 5.4
- GO Classification
- Functions4-hydroxyphenylpyruvate dioxygenase activity / metal ion bindingProcessesL-phenylalanine catabolic process / tyrosine catabolic process
- General Function
- Not Available
- Specific Function
- 4-hydroxyphenylpyruvate dioxygenase activity
- Pfam Domain Function
- Glyoxalase (PF00903)
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0012975|4-hydroxyphenylpyruvate dioxygenase (hpd) ATGACGCAGACCACACACCACACTCCCGACACCGCCCGGCAGGCCGACCCCTTCCCGGTG AAGGGAATGGACGCGGTCGTCTTCGCCGTAGGCAACGCCAAGCAGGCCGCGCACTACTAC TCCACCGCCTTCGGCATGCAGCTTGTGGCGTACTCCGGACCGGAGAACGGCAGCCGCGAG ACCGCTTCGTACGTCCTCACCAACGGCTCGGCACGCTTCGTCCTCACCTCCGTCATCAAG CCCGCCACCCCCTGGGGCCACTTCCTCGCCGACCATGTGGCCGAGCACGGCGACGGCGTC GTCGACCTCGCCATCGAGGTCCCGGACGCCCGCGCCGCCCACGCGTACGCGATCGAGCAC GGCGCCCGCTCGGTCGCCGAGCCGTACGAGCTGAAGGACGAGCACGGCACGGTCGTCCTC GCCGCGATCGCCACCTACGGCAAGACCCGCCACACCCTCGTCGACCGGACCGGCTACGAC GGCCCCTACCTCCCCGGCTACGTGGCCGCCGCCCCGATCGTCGAACCGCCCGCCCACCGC ACCTTCCAGGCCATCGACCACTGCGTCGGCAACGTCGAGCTCGGCCGGATGAACGAATGG GTCGGCTTCTACAACAAGGTCATGGGCTTCACGAACATGAAGGAGTTCGTGGGCGACGAC ATCGCGACCGAGTACTCGGCGCTGATGTCGAAGGTCGTGGCCGACGGCACGCTCAAGGTC AAGTTCCCGATCAACGAGCCCGCCCTCGCCAAGAAGAAGTCCCAGATCGACGAGTACCTG GAGTTCTACGGCGGCGCGGGCGTCCAGCACATCGCGCTGAACACGGGTGACATCGTCGAG ACGGTACGCACGATGCGCGCCGCCGGCGTCCAGTTCCTGGACACGCCCGACTCGTACTAC GACACCCTCGGGGAGTGGGTGGGCGACACCCGCGTCCCCGTCGACACCCTGCGCGAGCTG AAGATCCTCGCGGACCGCGACGAGGACGGCTATCTGCTCCAGATCTTCACCAAGCCGGTC CAGGACCGCCCGACGGTCTTCTTCGAGATCATCGAACGCCACGGCTCGATGGGATTCGGC AAGGGCAACTTCAAGGCCCTGTTCGAGGCGATCGAGCGGGAGCAGGAGAAGCGGGGCAAC CTGTAG
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q53586 UniProtKB Entry Name HPPD_STRAW GenBank Protein ID 555806 GenBank Gene ID U11864 PDB ID(s) 1T47 KEGG ID sma:SAV_5149 - General References
- Denoya CD, Skinner DD, Morgenstern MR: A Streptomyces avermitilis gene encoding a 4-hydroxyphenylpyruvic acid dioxygenase-like protein that directs the production of homogentisic acid and an ochronotic pigment in Escherichia coli. J Bacteriol. 1994 Sep;176(17):5312-9. [Article]
- Omura S, Ikeda H, Ishikawa J, Hanamoto A, Takahashi C, Shinose M, Takahashi Y, Horikawa H, Nakazawa H, Osonoe T, Kikuchi H, Shiba T, Sakaki Y, Hattori M: Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites. Proc Natl Acad Sci U S A. 2001 Oct 9;98(21):12215-20. Epub 2001 Sep 25. [Article]
- Ikeda H, Ishikawa J, Hanamoto A, Shinose M, Kikuchi H, Shiba T, Sakaki Y, Hattori M, Omura S: Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis. Nat Biotechnol. 2003 May;21(5):526-31. Epub 2003 Apr 14. [Article]
- Brownlee JM, Johnson-Winters K, Harrison DH, Moran GR: Structure of the ferrous form of (4-hydroxyphenyl)pyruvate dioxygenase from Streptomyces avermitilis in complex with the therapeutic herbicide, NTBC. Biochemistry. 2004 Jun 1;43(21):6370-7. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details 2-{HYDROXY[2-NITRO-4-(TRIFLUOROMETHYL)PHENYL]METHYLENE}CYCLOHEXANE-1,3-DIONE experimental unknown target Details