Transcriptional activator protein LasR
Details
- Name
- Transcriptional activator protein LasR
- Kind
- protein
- Synonyms
- Not Available
- Gene Name
- lasR
- UniProtKB Entry
- P25084Swiss-Prot
- Organism
- Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
- NCBI Taxonomy ID
- 208964
- Amino acid sequence
>lcl|BSEQ0019550|Transcriptional activator protein LasR MALVDGFLELERSSGKLEWSAILQKMASDLGFSKILFGLLPKDSQDYENAFIVGNYPAAW REHYDRAGYARVDPTVSHCTQSVLPIFWEPSIYQTRKQHEFFEEASAAGLVYGLTMPLHG ARGELGALSLSVEAENRAEANRFMESVLPTLWMLKDYALQSGAGLAFEHPVSKPVVLTSR EKEVLQWCAIGKTSWEISVICNCSEANVNFHMGNIRRKFGVTSRRVAAIMAVNLGLITL
- Number of residues
- 239
- Molecular Weight
- 26618.3
- Theoretical pI
- 6.51
- GO Classification
- FunctionsDNA binding / transcription factor activity, sequence-specific DNA bindingProcessespathogenesis / positive regulation of elastin biosynthetic process / positive regulation of transcription, DNA-templated / quorum sensing / regulation of elastin catabolic process / regulation of gene expression / regulation of transcription, DNA-templated / transcription, DNA-templated
- General Function
- Transcriptional activator of elastase structural gene (LasB). Binds to the PAI autoinducer.
- Specific Function
- DNA-binding transcription activator activity
- Pfam Domain Function
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasmic
- Gene sequence
>lcl|BSEQ0019551|Transcriptional activator protein LasR (lasR) ATGGCCTTGGTTGACGGTTTTCTTGAGCTGGAACGCTCAAGTGGAAAATTGGAGTGGAGC GCCATCCTGCAGAAGATGGCGAGCGACCTTGGATTCTCGAAGATCCTGTTCGGCCTGTTG CCTAAGGACAGCCAGGACTACGAGAACGCCTTCATCGTCGGCAACTACCCGGCCGCCTGG CGCGAGCATTACGACCGGGCTGGCTACGCGCGGGTCGACCCGACGGTCAGTCACTGTACC CAGAGCGTACTGCCGATTTTCTGGGAACCGTCCATCTACCAGACGCGAAAGCAGCACGAG TTCTTCGAGGAAGCCTCGGCCGCCGGCCTGGTGTATGGGCTGACCATGCCGCTGCATGGT GCTCGCGGCGAACTCGGCGCGCTGAGCCTCAGCGTGGAAGCGGAAAACCGGGCCGAGGCC AACCGTTTCATGGAGTCGGTCCTGCCGACCCTGTGGATGCTCAAGGACTACGCACTGCAG AGCGGTGCCGGACTGGCCTTCGAACATCCGGTCAGCAAACCGGTGGTTCTGACCAGCCGG GAGAAGGAAGTGTTGCAGTGGTGCGCCATCGGCAAGACCAGTTGGGAGATATCGGTTATC TGCAACTGCTCGGAAGCCAATGTGAACTTCCATATGGGAAATATTCGGCGGAAGTTCGGT GTGACCTCCCGCCGCGTAGCGGCCATTATGGCCGTTAATTTGGGTCTTATTACTCTCTGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P25084 UniProtKB Entry Name LASR_PSEAE GenBank Protein ID 151326 GenBank Gene ID M59425 PDB ID(s) 2UV0, 3IX3, 3IX4, 3IX8, 3JPU, 4NG2 KEGG ID pae:PA1430 NCBI Gene ID 881789 - General References
- Gambello MJ, Iglewski BH: Cloning and characterization of the Pseudomonas aeruginosa lasR gene, a transcriptional activator of elastase expression. J Bacteriol. 1991 May;173(9):3000-9. [Article]
- Fukushima J, Ishiwata T, Kurata M, You Z, Okuda K: Intracellular receptor-type transcription factor, LasR, contains a highly conserved amphipathic region which precedes the putative helix-turn-helix DNA binding motif. Nucleic Acids Res. 1994 Sep 11;22(18):3706-7. [Article]
- Stover CK, Pham XQ, Erwin AL, Mizoguchi SD, Warrener P, Hickey MJ, Brinkman FS, Hufnagle WO, Kowalik DJ, Lagrou M, Garber RL, Goltry L, Tolentino E, Westbrock-Wadman S, Yuan Y, Brody LL, Coulter SN, Folger KR, Kas A, Larbig K, Lim R, Smith K, Spencer D, Wong GK, Wu Z, Paulsen IT, Reizer J, Saier MH, Hancock RE, Lory S, Olson MV: Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen. Nature. 2000 Aug 31;406(6799):959-64. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details N-3-OXO-DODECANOYL-L-HOMOSERINE LACTONE experimental unknown target Details