Transcriptional activator protein LasR

Details

Name
Transcriptional activator protein LasR
Kind
protein
Synonyms
Not Available
Gene Name
lasR
UniProtKB Entry
P25084Swiss-Prot
Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
NCBI Taxonomy ID
208964
Amino acid sequence
>lcl|BSEQ0019550|Transcriptional activator protein LasR
MALVDGFLELERSSGKLEWSAILQKMASDLGFSKILFGLLPKDSQDYENAFIVGNYPAAW
REHYDRAGYARVDPTVSHCTQSVLPIFWEPSIYQTRKQHEFFEEASAAGLVYGLTMPLHG
ARGELGALSLSVEAENRAEANRFMESVLPTLWMLKDYALQSGAGLAFEHPVSKPVVLTSR
EKEVLQWCAIGKTSWEISVICNCSEANVNFHMGNIRRKFGVTSRRVAAIMAVNLGLITL
Number of residues
239
Molecular Weight
26618.3
Theoretical pI
6.51
GO Classification
Functions
DNA binding / transcription factor activity, sequence-specific DNA binding
Processes
pathogenesis / positive regulation of elastin biosynthetic process / positive regulation of transcription, DNA-templated / quorum sensing / regulation of elastin catabolic process / regulation of gene expression / regulation of transcription, DNA-templated / transcription, DNA-templated
General Function
Transcriptional activator of elastase structural gene (LasB). Binds to the PAI autoinducer.
Specific Function
DNA-binding transcription activator activity
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
Not Available
Cellular Location
Cytoplasmic
Gene sequence
>lcl|BSEQ0019551|Transcriptional activator protein LasR (lasR)
ATGGCCTTGGTTGACGGTTTTCTTGAGCTGGAACGCTCAAGTGGAAAATTGGAGTGGAGC
GCCATCCTGCAGAAGATGGCGAGCGACCTTGGATTCTCGAAGATCCTGTTCGGCCTGTTG
CCTAAGGACAGCCAGGACTACGAGAACGCCTTCATCGTCGGCAACTACCCGGCCGCCTGG
CGCGAGCATTACGACCGGGCTGGCTACGCGCGGGTCGACCCGACGGTCAGTCACTGTACC
CAGAGCGTACTGCCGATTTTCTGGGAACCGTCCATCTACCAGACGCGAAAGCAGCACGAG
TTCTTCGAGGAAGCCTCGGCCGCCGGCCTGGTGTATGGGCTGACCATGCCGCTGCATGGT
GCTCGCGGCGAACTCGGCGCGCTGAGCCTCAGCGTGGAAGCGGAAAACCGGGCCGAGGCC
AACCGTTTCATGGAGTCGGTCCTGCCGACCCTGTGGATGCTCAAGGACTACGCACTGCAG
AGCGGTGCCGGACTGGCCTTCGAACATCCGGTCAGCAAACCGGTGGTTCTGACCAGCCGG
GAGAAGGAAGTGTTGCAGTGGTGCGCCATCGGCAAGACCAGTTGGGAGATATCGGTTATC
TGCAACTGCTCGGAAGCCAATGTGAACTTCCATATGGGAAATATTCGGCGGAAGTTCGGT
GTGACCTCCCGCCGCGTAGCGGCCATTATGGCCGTTAATTTGGGTCTTATTACTCTCTGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP25084
UniProtKB Entry NameLASR_PSEAE
GenBank Protein ID151326
GenBank Gene IDM59425
PDB ID(s)2UV0, 3IX3, 3IX4, 3IX8, 3JPU, 4NG2
KEGG IDpae:PA1430
NCBI Gene ID881789
General References
  1. Gambello MJ, Iglewski BH: Cloning and characterization of the Pseudomonas aeruginosa lasR gene, a transcriptional activator of elastase expression. J Bacteriol. 1991 May;173(9):3000-9. [Article]
  2. Fukushima J, Ishiwata T, Kurata M, You Z, Okuda K: Intracellular receptor-type transcription factor, LasR, contains a highly conserved amphipathic region which precedes the putative helix-turn-helix DNA binding motif. Nucleic Acids Res. 1994 Sep 11;22(18):3706-7. [Article]
  3. Stover CK, Pham XQ, Erwin AL, Mizoguchi SD, Warrener P, Hickey MJ, Brinkman FS, Hufnagle WO, Kowalik DJ, Lagrou M, Garber RL, Goltry L, Tolentino E, Westbrock-Wadman S, Yuan Y, Brody LL, Coulter SN, Folger KR, Kas A, Larbig K, Lim R, Smith K, Spencer D, Wong GK, Wu Z, Paulsen IT, Reizer J, Saier MH, Hancock RE, Lory S, Olson MV: Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen. Nature. 2000 Aug 31;406(6799):959-64. [Article]

Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
N-3-OXO-DODECANOYL-L-HOMOSERINE LACTONEexperimentalunknowntargetDetails