Long-chain-fatty-acid--CoA ligase ACSBG1
Details
- Name
- Long-chain-fatty-acid--CoA ligase ACSBG1
- Kind
- protein
- Synonyms
- 6.2.1.3
- Acyl-CoA synthetase bubblegum family member 1
- BGM
- hBG1
- hsBG
- hsBGM
- KIAA0631
- Lipidosin
- LPD
- Gene Name
- ACSBG1
- UniProtKB Entry
- Q96GR2Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0037276|Long-chain-fatty-acid--CoA ligase ACSBG1 MPRNSGAGYGCPHGDPSMLDSRETPQESRQDMIVRTTQEKLKTSSLTDRQPLSKESLNHA LELSVPEKVNNAQWDAPEEALWTTRADGRVRLRIDPSCPQLPYTVHRMFYEALDKYGDLI ALGFKRQDKWEHISYSQYYLLARRAAKGFLKLGLKQAHSVAILGFNSPEWFFSAVGTVFA GGIVTGIYTTSSPEACQYIAYDCCANVIMVDTQKQLEKILKIWKQLPHLKAVVIYKEPPP NKMANVYTMEEFMELGNEVPEEALDAIIDTQQPNQCCVLVYTSGTTGNPKGVMLSQDNIT WTARYGSQAGDIRPAEVQQEVVVSYLPLSHIAAQIYDLWTGIQWGAQVCFAEPDALKGSL VNTLREVEPTSHMGVPRVWEKIMERIQEVAAQSGFIRRKMLLWAMSVTLEQNLTCPGSDL KPFTTRLADYLVLAKVRQALGFAKCQKNFYGAAPMMAETQHFFLGLNIRLYAGYGLSETS GPHFMSSPYNYRLYSSGKLVPGCRVKLVNQDAEGIGEICLWGRTIFMGYLNMEDKTCEAI DEEGWLHTGDAGRLDADGFLYITGRLKELIITAGGENVPPVPIEEAVKMELPIISNAMLI GDQRKFLSMLLTLKCTLDPDTSDQTDNLTEQAMEFCQRVGSRATTVSEIIEKKDEAVYQA IEEGIRRVNMNAAARPYHIQKWAILERDFSISGGELGPTMKLKRLTVLEKYKGIIDSFYQ EQKM
- Number of residues
- 724
- Molecular Weight
- 81289.605
- Theoretical pI
- 5.86
- GO Classification
- FunctionsATP binding / long-chain fatty acid-CoA ligase activity / very long-chain fatty acid-CoA ligase activityProcesseslong-chain fatty acid metabolic process / long-chain fatty-acyl-CoA biosynthetic process / myelination / response to glucocorticoid / very long-chain fatty acid metabolic processComponentscytoplasm / cytosol / endoplasmic reticulum
- General Function
- Catalyzes the conversion of fatty acids such as long-chain and very long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:10954726, PubMed:12975357, PubMed:24269233). Can activate diverse saturated, monosaturated and polyunsaturated fatty acids (PubMed:10954726)
- Specific Function
- ATP binding
- Pfam Domain Function
- AMP-binding (PF00501)
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0012978|Long-chain-fatty-acid--CoA ligase ACSBG1 (ACSBG1) ATGCCACGCAATTCTGGAGCTGGATACGGCTGCCCACACGGGGACCCCAGCATGCTGGAC AGCAGAGAGACCCCACAGGAGAGCCGGCAGGACATGATTGTGAGGACCACCCAAGAAAAA TTGAAAACCAGCTCACTGACTGACAGGCAGCCACTCTCCAAAGAGTCCCTGAACCATGCT CTCGAGCTCTCAGTGCCAGAGAAGGTGAATAATGCCCAGTGGGATGCTCCAGAGGAGGCG CTGTGGACGACTCGGGCCGATGGGCGGGTGCGCCTGCGCATAGACCCCAGCTGCCCACAG CTTCCCTACACTGTGCATCGGATGTTCTACGAGGCCCTGGATAAGTATGGGGACCTCATC GCTTTGGGCTTCAAGCGCCAGGACAAGTGGGAACACATCTCCTACTCCCAATACTACCTG CTCGCCCGCAGAGCCGCCAAGGGCTTCCTGAAGCAGGCCCACAGTGTGGCCATCCTCGGC TTCAACTCCCCGGAGTGGTTCTTCTCGGCAGTGGGCACAGTATTTGCAGGTGGCATCGTC ACTGGCATCTACACCACCAGCTCCCCAGAGGCCTGCCAGTACATCGCTTATGACTGCTGC GCCAATGTCATCATGGTCGACACGCAGAAGCAGCTGGAAAAGATCCTGAAGATCTGGAAA CAGTTGCCACATCTAAAGGCAGTCGTGATATATAAAGAACCTCCTCCAAACAAGATGGCC AATGTGTACACGATGGAGGAATTCATGGAGCTGGGGAATGAAGTGCCTGAGGAAGCCCTG GACGCCATCATTGACACCCAGCAGCCCAACCAGTGCTGTGTGCTAGTCTACACTTCCGGC ACCACTGGGAACCCCAAGGGCGTGATGCTGAGTCAAGACAATATCACGTGGACGGCACGG TACGGCAGCCAGGCCGGTGACATCCGGCCGGCAGAAGTCCAGCAGGAGGTGGTAGTCAGC TACCTGCCCCTCAGCCATATTGCCGCCCAGATCTACGACCTGTGGACAGGCATCCAGTGG GGGGCCCAGGTTTGCTTTGCCGAACCCGACGCCCTGAAGGGGAGCCTGGTGAACACGCTG CGGGAGGTGGAGCCCACATCACACATGGGGGTGCCCCGGGTATGGGAGAAGATCATGGAG CGCATCCAGGAGGTGGCGGCTCAGTCTGGCTTCATCCGGCGAAAGATGCTGCTGTGGGCC ATGTCGGTGACCTTGGAGCAGAACCTCACCTGCCCCGGCAGCGACCTGAAGCCCTTCACA ACCAGACTGGCAGATTACCTGGTGCTAGCCAAGGTTCGCCAGGCACTGGGATTTGCCAAG TGTCAAAAGAACTTCTATGGAGCGGCCCCCATGATGGCAGAGACACAGCACTTCTTCCTG GGTCTCAACATCCGCTTGTATGCGGGCTACGGCCTCAGTGAGACCTCAGGCCCCCACTTC ATGTCCAGTCCCTACAACTACCGGCTGTACAGCTCAGGCAAGTTGGTGCCCGGCTGTCGG GTGAAGCTGGTGAACCAGGACGCAGAGGGCATTGGCGAGATCTGCCTGTGGGGCCGCACC ATATTCATGGGCTACCTGAACATGGAGGACAAGACTTGTGAGGCCATCGACGAGGAAGGC TGGCTGCACACGGGTGATGCTGGCCGCCTGGACGCCGATGGCTTCCTCTACATCACTGGG CGCCTCAAAGAATTAATCATCACAGCTGGTGGGGAGAATGTGCCCCCTGTGCCCATCGAG GAGGCCGTGAAGATGGAGCTGCCCATCATCAGCAACGCCATGCTCATTGGGGACCAGAGG AAGTTCCTGTCCATGCTGCTCACCTTGAAGTGCACTCTGGACCCAGACACCTCTGACCAG ACTGATAATCTGACTGAACAAGCTATGGAGTTCTGCCAGAGGGTGGGCAGCAGAGCCACC ACAGTGTCCGAGATCATAGAGAAGAAGGATGAGGCCGTGTACCAGGCCATCGAAGAGGGG ATCCGGAGGGTCAACATGAACGCGGCGGCCCGGCCCTACCACATCCAGAAGTGGGCCATT CTCGAGAGAGACTTCTCCATTTCGGGTGGAGAGTTGGGTCCCACGATGAAACTGAAACGG CTCACAGTTTTGGAGAAGTACAAAGGTATCATTGACTCCTTTTACCAAGAGCAAAAAATG TAA
- Chromosome Location
- 15
- Locus
- 15q25.1
- External Identifiers
Resource Link UniProtKB ID Q96GR2 UniProtKB Entry Name ACBG1_HUMAN GenBank Protein ID 9957538 GenBank Gene ID AF179481 GeneCard ID ACSBG1 HGNC ID HGNC:29567 KEGG ID hsa:23205 NCBI Gene ID 23205 - General References
- Steinberg SJ, Morgenthaler J, Heinzer AK, Smith KD, Watkins PA: Very long-chain acyl-CoA synthetases. Human "bubblegum" represents a new family of proteins capable of activating very long-chain fatty acids. J Biol Chem. 2000 Nov 10;275(45):35162-9. [Article]
- Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O: Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. DNA Res. 1998 Jun 30;5(3):169-76. [Article]
- Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. DNA Res. 2002 Jun 30;9(3):99-106. [Article]
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- Zody MC, Garber M, Sharpe T, Young SK, Rowen L, O'Neill K, Whittaker CA, Kamal M, Chang JL, Cuomo CA, Dewar K, FitzGerald MG, Kodira CD, Madan A, Qin S, Yang X, Abbasi N, Abouelleil A, Arachchi HM, Baradarani L, Birditt B, Bloom S, Bloom T, Borowsky ML, Burke J, Butler J, Cook A, DeArellano K, DeCaprio D, Dorris L 3rd, Dors M, Eichler EE, Engels R, Fahey J, Fleetwood P, Friedman C, Gearin G, Hall JL, Hensley G, Johnson E, Jones C, Kamat A, Kaur A, Locke DP, Madan A, Munson G, Jaffe DB, Lui A, Macdonald P, Mauceli E, Naylor JW, Nesbitt R, Nicol R, O'Leary SB, Ratcliffe A, Rounsley S, She X, Sneddon KM, Stewart S, Sougnez C, Stone SM, Topham K, Vincent D, Wang S, Zimmer AR, Birren BW, Hood L, Lander ES, Nusbaum C: Analysis of the DNA sequence and duplication history of human chromosome 15. Nature. 2006 Mar 30;440(7084):671-5. [Article]
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- Pei Z, Oey NA, Zuidervaart MM, Jia Z, Li Y, Steinberg SJ, Smith KD, Watkins PA: The acyl-CoA synthetase "bubblegum" (lipidosin): further characterization and role in neuronal fatty acid beta-oxidation.. J Biol Chem. 2003 Nov 21;278(47):47070-8. Epub 2003 Sep 15. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details 2-(6-HYDROXY-1,3-BENZOTHIAZOL-2-YL)-1,3-THIAZOL-4(5H)-ONE experimental unknown target Details