o-succinylbenzoate synthase

BE0004273ProteinThermobifida fusca (strain YX)menC

Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB) (PubMed:24060347, PubMed:24872444). It is acted on by 1 drug in DrugBank.

Gene name
menC
UniProtKB entry
Q47Q21TrEMBL
Residues / weight
317 residues · 34,100 Da
Also known as
4-(2'-carboxyphenyl)-4-oxybutyric acid synthase · 4.2.1.113 · o-succinylbenzoic acid synthase · OSB synthase

Resolves to

Protein
UniProtQ47Q21UniProt nameMENC_THEFY
Gene
GenBank71914139
Pharmacology
KEGGtfu:Tfu_1410
Structure
PDB2OPJPDB2QVH
Drugs

What you can answer from here — as of September 04, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which compounds in development act on o-succinylbenzoate synthase, and which indications are they being tested in?

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