Trafficking protein particle complex subunit 4
Details
- Name
- Trafficking protein particle complex subunit 4
- Kind
- protein
- Synonyms
- Hematopoietic stem/progenitor cell protein 172
- SBDN
- Synbindin
- TRS23 homolog
- Gene Name
- TRAPPC4
- UniProtKB Entry
- Q9Y296Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0008133|Trafficking protein particle complex subunit 4 MAIFSVYVVNKAGGLIYQLDSYAPRAEAEKTFSYPLDLLLKLHDERVLVAFGQRDGIRVG HAVLAINGMDVNGRYTADGKEVLEYLGNPANYPVSIRFGRPRLTSNEKLMLASMFHSLFA IGSQLSPEQGSSGIEMLETDTFKLHCYQTLTGIKFVVLADPRQAGIDSLLRKIYEIYSDF ALKNPFYSLEMPIRCELFDQNLKLALEVAEKAGTFGPGS
- Number of residues
- 219
- Molecular Weight
- 24339.76
- Theoretical pI
- 6.12
- GO Classification
- ProcessesCOPII vesicle coating / dendrite developmentComponentscytosol / dendrite / endoplasmic reticulum / Golgi membrane / Golgi stack / synapse / synaptic vesicle / TRAPP complex
- General Function
- Core component of the TRAPP complexes which has a function of guanine nucleotide exchange factor activity for Rab1 GTPase (Probable). Plays a role in vesicular transport from endoplasmic reticulum to Golgi and autophagy (PubMed:31794024). May play a role in dendrite postsynaptic membrane trafficking (By similarity)
- Specific Function
- Not Available
- Pfam Domain Function
- Sybindin (PF04099)
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Postsynaptic cell membrane
- Gene sequence
>lcl|BSEQ0021383|Trafficking protein particle complex subunit 4 (TRAPPC4) ATGGCGATTTTTAGTGTGTATGTGGTGAACAAAGCTGGCGGCTTGATTTACCAGTTGGAC AGCTACGCGCCACGGGCTGAGGCTGAGAAAACTTTCAGTTATCCGCTGGATCTGCTGCTC AAGCTACACGATGAGCGTGTGTTGGTTGCTTTCGGCCAGCGGGACGGCATCCGAGTGGGT CATGCAGTGCTGGCCATCAATGGCATGGACGTGAATGGCAGGTACACGGCCGACGGGAAA GAGGTGCTGGAGTATCTGGGTAACCCTGCTAATTACCCGGTGTCCATTCGATTTGGCCGG CCCCGCCTCACTTCTAATGAGAAGCTTATGCTGGCCTCCATGTTCCACTCGCTCTTTGCC ATCGGCTCCCAGCTGTCTCCTGAACAGGGAAGCTCAGGCATTGAGATGCTGGAGACAGAC ACATTCAAATTGCACTGCTACCAGACACTGACAGGGATCAAGTTTGTGGTTCTAGCAGAT CCTAGGCAAGCTGGAATAGATTCTCTTCTCCGAAAGATTTATGAGATTTACTCAGACTTT GCCCTCAAGAATCCATTCTATTCCTTAGAAATGCCTATCAGGTGTGAGCTCTTTGACCAG AACCTGAAGCTAGCTCTGGAGGTGGCAGAGAAGGCTGGAACTTTTGGACCTGGGTCATAG
- Chromosome Location
- 11
- Locus
- 11q23.3
- External Identifiers
Resource Link UniProtKB ID Q9Y296 UniProtKB Entry Name TPPC4_HUMAN GenBank Protein ID 6650543 GenBank Gene ID AF105025 GeneCard ID TRAPPC4 HGNC ID HGNC:19943 PDB ID(s) 2J3T, 2JSN, 2ZMV KEGG ID hsa:51399 NCBI Gene ID 51399 - General References
- Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. Genome Res. 2000 Oct;10(10):1546-60. [Article]
- Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. Genome Res. 2000 May;10(5):703-13. [Article]
- Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
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- Gavin AC, Bosche M, Krause R, Grandi P, Marzioch M, Bauer A, Schultz J, Rick JM, Michon AM, Cruciat CM, Remor M, Hofert C, Schelder M, Brajenovic M, Ruffner H, Merino A, Klein K, Hudak M, Dickson D, Rudi T, Gnau V, Bauch A, Bastuck S, Huhse B, Leutwein C, Heurtier MA, Copley RR, Edelmann A, Querfurth E, Rybin V, Drewes G, Raida M, Bouwmeester T, Bork P, Seraphin B, Kuster B, Neubauer G, Superti-Furga G: Functional organization of the yeast proteome by systematic analysis of protein complexes. Nature. 2002 Jan 10;415(6868):141-7. [Article]
- Scrivens PJ, Shahrzad N, Moores A, Morin A, Brunet S, Sacher M: TRAPPC2L is a novel, highly conserved TRAPP-interacting protein. Traffic. 2009 Jun;10(6):724-36. doi: 10.1111/j.1600-0854.2009.00906.x. Epub 2009 Mar 3. [Article]
- Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Burckstummer T, Bennett KL, Superti-Furga G, Colinge J: Initial characterization of the human central proteome. BMC Syst Biol. 2011 Jan 26;5:17. doi: 10.1186/1752-0509-5-17. [Article]
- Scrivens PJ, Noueihed B, Shahrzad N, Hul S, Brunet S, Sacher M: C4orf41 and TTC-15 are mammalian TRAPP components with a role at an early stage in ER-to-Golgi trafficking. Mol Biol Cell. 2011 Jun 15;22(12):2083-93. doi: 10.1091/mbc.E10-11-0873. Epub 2011 Apr 27. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details S-palmitoyl-L-cysteine experimental unknown target Details