Protein mono-ADP-ribosyltransferase PARP15

BE0004283ProteinHumansPARP15

Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins (PubMed:16061477, PubMed:25043379, PubMed:25635049). It is acted on by 1 drug in DrugBank.

Gene name
PARP15
UniProtKB entry
Q460N3Swiss-Prot
Cellular location
Nucleus
Residues / weight
678 residues · 74,575 Da
Also known as
2.4.2.- · ADP-ribosyltransferase diphtheria toxin-like 7 · ARTD7 · B-aggressive lymphoma protein 3 · BAL3

Resolves to

Protein
UniProtQ460N3UniProt namePAR15_HUMAN
Gene
HGNCHGNC:26876NCBI Gene165631GenBank67078854GeneCardsPARP15
Pharmacology
IUPHAR/GtoPdb3270KEGGhsa:165631
Structure
PDB3BLJPDB3GEYPDB3V2B
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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7GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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8+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Protein mono-ADP-ribosyltransferase PARP15, and which indications are they being tested in?

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