Protein mono-ADP-ribosyltransferase PARP15

Details

Name
Protein mono-ADP-ribosyltransferase PARP15
Kind
protein
Synonyms
  • 2.4.2.-
  • ADP-ribosyltransferase diphtheria toxin-like 7
  • ARTD7
  • B-aggressive lymphoma protein 3
  • BAL3
  • PARP-15
  • Poly [ADP-ribose] polymerase 15
Gene Name
PARP15
UniProtKB Entry
Q460N3Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0037277|Protein mono-ADP-ribosyltransferase PARP15
MAAPGPLPAAALSPGAPTPRELMHGVAGVTSRAGRDREAGSVLPAGNRGARKASRRSSSR
SMSRDNKFSKKDCLSIRNVVASIQTKEGLNLKLISGDVLYIWADVIVNSVPMNLQLGGGP
LSRAFLQKAGPMLQKELDDRRRETEEKVGNIFMTSGCNLDCKAVLHAVAPYWNNGAETSW
QIMANIIKKCLTTVEVLSFSSITFPMIGTGSLQFPKAVFAKLILSEVFEYSSSTRPITSP
LQEVHFLVYTNDDEGCQAFLDEFTNWSRINPNKARIPMAGDTQGVVGTVSKPCFTAYEMK
IGAITFQVATGDIATEQVDVIVNSTARTFNRKSGVSRAILEGAGQAVESECAVLAAQPHR
DFIITPGGCLKCKIIIHVPGGKDVRKTVTSVLEECEQRKYTSVSLPAIGTGNAGKNPITV
ADNIIDAIVDFSSQHSTPSLKTVKVVIFQPELLNIFYDSMKKRDLSASLNFQSTFSMTTC
NLPEHWTDMNHQLFCMVQLEPGQSEYNTIKDKFTRTCSSYAIEKIERIQNAFLWQSYQVK
KRQMDIKNDHKNNERLLFHGTDADSVPYVNQHGFNRSCAGKNAVSYGKGTYFAVDASYSA
KDTYSKPDSNGRKHMYVVRVLTGVFTKGRAGLVTPPPKNPHNPTDLFDSVTNNTRSPKLF
VVFFDNQAYPEYLITFTA
Number of residues
678
Molecular Weight
74575.465
Theoretical pI
9.06
GO Classification
Functions
NAD+ ADP-ribosyltransferase activity
Components
nucleus
General Function
Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins (PubMed:16061477, PubMed:25043379, PubMed:25635049). Acts as a negative regulator of transcription (PubMed:16061477)
Specific Function
NAD+ ADP-ribosyltransferase activity
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
Not Available
Cellular Location
Nucleus
Gene sequence
>lcl|BSEQ0019552|Poly [ADP-ribose] polymerase 15 (PARP15)
ATGGCTGCGCCAGGCCCCCTTCCTGCCGCTGCTCTGAGTCCAGGGGCTCCGACCCCCAGA
GAACTTATGCACGGAGTTGCAGGTGTTACTTCCAGAGCCGGACGAGATCGGGAGGCGGGG
AGCGTGCTGCCGGCCGGGAACCGTGGGGCGCGGAAGGCCTCCCGGCGCTCTTCCTCCCGG
AGTATGTCCAGAGACAACAAGTTCAGCAAGAAAGATTGTCTTTCAATCAGGAATGTTGTA
GCTTCAATCCAAACCAAAGAAGGTCTGAATCTCAAGTTGATAAGTGGAGATGTTCTGTAC
ATCTGGGCCGATGTCATTGTCAACAGCGTTCCCATGAATCTTCAGCTTGGAGGAGGACCA
CTATCTCGGGCATTTTTGCAGAAAGCTGGTCCCATGCTCCAGAAAGAGTTAGATGACAGA
AGGCGGGAAACAGAGGAAAAAGTAGGTAACATATTCATGACAAGCGGCTGCAATCTGGAC
TGCAAAGCTGTGCTCCATGCTGTGGCTCCATACTGGAATAATGGAGCAGAGACTTCTTGG
CAGATCATGGCAAATATAATCAAGAAATGTTTGACAACTGTAGAAGTGCTATCTTTCTCA
TCAATCACATTTCCCATGATTGGAACAGGAAGTTTGCAGTTTCCCAAAGCTGTTTTTGCT
AAACTAATCCTTTCAGAAGTGTTCGAATACAGTAGCAGCACAAGGCCGATAACTAGCCCT
TTACAAGAAGTCCACTTTCTGGTATATACAAATGACGATGAAGGCTGTCAGGCATTTTTA
GATGAATTCACTAACTGGTCAAGAATAAATCCCAACAAGGCCAGGATTCCCATGGCAGGA
GATACCCAAGGTGTGGTCGGGACTGTCTCTAAGCCTTGTTTCACAGCATATGAAATGAAA
ATCGGTGCAATTACTTTTCAGGTTGCTACTGGAGATATAGCCACTGAACAGGTAGATGTT
ATTGTAAACTCAACAGCAAGGACATTTAATCGGAAATCAGGTGTGTCAAGAGCTATTTTA
GAAGGTGCTGGACAAGCTGTGGAAAGTGAATGTGCTGTACTAGCTGCACAGCCTCACAGA
GATTTTATAATTACACCAGGTGGATGCTTAAAGTGCAAAATAATAATTCATGTTCCTGGG
GGAAAAGATGTCAGGAAAACGGTCACCAGTGTTCTAGAAGAGTGTGAACAGAGGAAGTAC
ACATCGGTTTCCCTTCCAGCCATTGGAACAGGAAATGCCGGAAAAAACCCTATCACAGTT
GCTGATAACATAATCGATGCTATTGTAGACTTCTCATCACAACATTCCACCCCATCATTA
AAAACAGTTAAAGTTGTCATTTTTCAACCTGAGCTGCTAAATATATTCTACGACAGCATG
AAAAAAAGAGACCTCTCTGCATCACTGAACTTTCAGTCCACATTCTCCATGACTACATGT
AATCTTCCTGAACACTGGACTGACATGAATCATCAGCTGTTTTGCATGGTCCAGCTAGAG
CCAGGACAATCAGAATATAATACCATAAAGGACAAGTTCACCCGAACTTGTTCTTCCTAC
GCAATAGAGAAGATTGAGAGGATACAGAATGCATTTCTCTGGCAGAGCTACCAGGTAAAG
AAAAGGCAAATGGATATCAAGAATGACCATAAGAATAATGAGAGACTCCTCTTCCATGGG
ACAGATGCAGACTCAGTGCCATATGTCAATCAGCACGGCTTTAATAGAAGTTGTGCTGGG
AAAAATGCTGTATCCTATGGAAAAGGAACCTATTTTGCTGTGGATGCCAGTTATTCTGCC
AAGGACACCTACTCCAAGCCAGACAGCAATGGGAGAAAGCACATGTACGTTGTGCGAGTA
CTTACTGGAGTCTTCACAAAGGGACGTGCAGGATTAGTCACCCCTCCACCCAAGAATCCT
CACAATCCCACAGATCTCTTTGACTCAGTGACAAACAATACACGATCTCCAAAGCTATTT
GTGGTATTCTTTGATAATCAGGCTTACCCAGAATATCTCATAACTTTCACGGCTTAA
Chromosome Location
3
Locus
3q21.1
External Identifiers
ResourceLink
UniProtKB IDQ460N3
UniProtKB Entry NamePAR15_HUMAN
GenBank Protein ID67078854
GenBank Gene IDDQ063586
GeneCard IDPARP15
HGNC IDHGNC:26876
PDB ID(s)3BLJ, 3GEY, 3V2B, 4F0E, 6EK3, 6RY4, 7F41, 7F42, 7F43, 7OQQ, 7OSP, 7OSS, 7OSX, 7OTF, 7OTH, 7OUW, 7OUX, 7PW3, 7PWA, 7PWC, 7PWK, 7PWL, 7PWM, 7PWP, 7PWQ, 7PWR, 7PWS, 7PWU, 7PWW, 7PX6, 7PX7, 7R3O, 7R4A, 7R5D, 7Z1V, 7Z1W, 7Z1Y, 7Z2O, 7Z2Q, 7Z41
KEGG IDhsa:165631
IUPHAR/Guide To Pharmacology ID3270
NCBI Gene ID165631
General References
  1. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
  2. Muzny DM, Scherer SE, Kaul R, Wang J, Yu J, Sudbrak R, Buhay CJ, Chen R, Cree A, Ding Y, Dugan-Rocha S, Gill R, Gunaratne P, Harris RA, Hawes AC, Hernandez J, Hodgson AV, Hume J, Jackson A, Khan ZM, Kovar-Smith C, Lewis LR, Lozado RJ, Metzker ML, Milosavljevic A, Miner GR, Morgan MB, Nazareth LV, Scott G, Sodergren E, Song XZ, Steffen D, Wei S, Wheeler DA, Wright MW, Worley KC, Yuan Y, Zhang Z, Adams CQ, Ansari-Lari MA, Ayele M, Brown MJ, Chen G, Chen Z, Clendenning J, Clerc-Blankenburg KP, Chen R, Chen Z, Davis C, Delgado O, Dinh HH, Dong W, Draper H, Ernst S, Fu G, Gonzalez-Garay ML, Garcia DK, Gillett W, Gu J, Hao B, Haugen E, Havlak P, He X, Hennig S, Hu S, Huang W, Jackson LR, Jacob LS, Kelly SH, Kube M, Levy R, Li Z, Liu B, Liu J, Liu W, Lu J, Maheshwari M, Nguyen BV, Okwuonu GO, Palmeiri A, Pasternak S, Perez LM, Phelps KA, Plopper FJ, Qiang B, Raymond C, Rodriguez R, Saenphimmachak C, Santibanez J, Shen H, Shen Y, Subramanian S, Tabor PE, Verduzco D, Waldron L, Wang J, Wang J, Wang Q, Williams GA, Wong GK, Yao Z, Zhang J, Zhang X, Zhao G, Zhou J, Zhou Y, Nelson D, Lehrach H, Reinhardt R, Naylor SL, Yang H, Olson M, Weinstock G, Gibbs RA: The DNA sequence, annotation and analysis of human chromosome 3. Nature. 2006 Apr 27;440(7088):1194-8. [Article]
  3. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
  4. Aguiar RC, Takeyama K, He C, Kreinbrink K, Shipp MA: B-aggressive lymphoma family proteins have unique domains that modulate transcription and exhibit poly(ADP-ribose) polymerase activity. J Biol Chem. 2005 Oct 7;280(40):33756-65. Epub 2005 Aug 1. [Article]
  5. Hottiger MO, Hassa PO, Luscher B, Schuler H, Koch-Nolte F: Toward a unified nomenclature for mammalian ADP-ribosyltransferases. Trends Biochem Sci. 2010 Apr;35(4):208-19. doi: 10.1016/j.tibs.2009.12.003. Epub 2010 Jan 26. [Article]

Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
N~2~,N~2~-DIMETHYL-N~1~-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)GLYCINAMIDEexperimentalunknowntargetDetails