[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial

BE0004284ProteinHumansPDK4

Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. It is acted on by 4 drugs in DrugBank.

Gene name
PDK4
UniProtKB entry
Q16654Swiss-Prot
Cellular location
Mitochondrion matrix
Residues / weight
411 residues · 46,469 Da
Also known as
2.7.11.2 · PDHK4 · Pyruvate dehydrogenase kinase isoform 4

Resolves to

Protein
UniProtQ16654UniProt namePDK4_HUMAN
Gene
HGNCHGNC:8812NCBI Gene5166GenBank1399197GeneCardsPDK4
Pharmacology
IUPHAR/GtoPdb2144KEGGhsa:5166
Structure
PDB2E0APDB2ZDXPDB2ZDY
Drugs

What you can answer from here — as of September 03, 2024

4DrugsApproved to experimental, with action, bond type and pharmacological action
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15GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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16+ReferencesStructured and connected to the statements they support
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Which approved drugs act on [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial, how selective are they, and which programs against it are still in active trials?

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